Neurological consequences of systemic inflammation in the premature neonate
| Autor: | Peter J. Giannone, Hong Huang, John Anthony Bauer, Aparna Patra |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Systemic inflammation
Bioinformatics Chorioamnionitis lcsh:RC346-429 Sepsis 03 medical and health sciences 0302 clinical medicine Immune system Developmental Neuroscience Neuroimaging extremely premature infants systemic inflammation white matter injury neurodevelopmental impairment cytokines 030225 pediatrics medicine lcsh:Neurology. Diseases of the nervous system Invited Review business.industry medicine.disease Bronchopulmonary dysplasia Necrotizing enterocolitis medicine.symptom business Meningitis 030217 neurology & neurosurgery |
| Zdroj: | Neural Regeneration Research, Vol 12, Iss 6, Pp 890-896 (2017) Neural Regeneration Research |
| ISSN: | 1673-5374 |
| Popis: | Despite substantial progress in neonatal care over the past two decades leading to improved survival of extremely premature infants, extreme prematurity continues to be associated with long term neurodevelopmental impairments. Cerebral white matter injury is the predominant form of insult in preterm brain leading to adverse neurological consequences. Such brain injury pattern and unfavorable neurologic sequelae is commonly encountered in premature infants exposed to systemic inflammatory states such as clinical or culture proven sepsis with or without evidence of meningitis, prolonged mechanical ventilation, bronchopulmonary dysplasia, necrotizing enterocolitis and chorioamnionitis. Underlying mechanisms may include cytokine mediated processes without direct entry of pathogens into the brain, developmental differences in immune response and complex neurovascular barrier system that play a critical role in regulating the cerebral response to various systemic inflammatory insults in premature infants. Understanding of these pathologic mechanisms and clinical correlates of such injury based on serum biomarkers or brain imaging findings on magnetic resonance imaging will pave way for future research and translational therapeutic opportunities for the developing brain. |
| Databáze: | OpenAIRE |
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