Spectrum of complications of severe DKA in children in pediatric Intensive Care Unit
| Autor: | Anwar Ul Haque, Khadija Nuzhat Humayun, Qalab Abbas, Saba Arbab |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pediatrics
medicine.medical_specialty Complications Diabetic ketoacidosis medicine.medical_treatment 03 medical and health sciences 0302 clinical medicine Hyperchloremia 030225 pediatrics medicine Pediatric intensive care unit Renal replacement therapy Pediatric Mechanical ventilation business.industry Acute kidney injury 030208 emergency & critical care medicine General Medicine medicine.disease Hypokalemia Original Article medicine.symptom Hyponatremia business |
| Zdroj: | Pakistan Journal of Medical Sciences |
| ISSN: | 1681-715X |
| DOI: | 10.12669/pjms.341.13875 |
| Popis: | Objectives To describe the spectrum of complications of Diabetic Ketoacidosis (DKA) observed in children admitted with severe DKA. Methods Retrospective review of the medical records of all children admitted with the diagnosis of severe DKA in Pediatric Intensive Care Unit (PICU) of the Aga Khan University Hospital, from January 2010 to December 2015 was done. Data was collected on a structured proforma and descriptive statistics were applied. Results Total 37 children were admitted with complicated DKA (1.9% of total PICU admission with 1.8% in 2010 and 3.4% in 2015). Mean age of study population was 8.1±4.6 years and 70% were females (26/37). Mean Prism III score was 9.4±6, mean GCS on presentation was 11±3.8 and mean lowest pH was 7.00±0.15. Complications observed included hyperchloremia (35.94%), hypokalemia (30.81%), hyponatremia (26.70%), cerebral edema (16.43%), shock (13.35%), acute kidney injury (10.27%), arrhythmias (3.8%), and thrombotic thrombocytopenic purpura (5.4%), while one patient had myocarditis and ARDS each. 13/37 children (35%) needed inotropic support, 11/37 (30%) required mechanical ventilation while only one patient required renal replacement therapy. Two patients (5.4%) died during their PICU stay. Conclusion Hyperchloremia and other electrolyte abnormalities, cerebral edema and AKI are the most common complications of severe DKA. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|