Conjugate additions of lithium dialkynylcuprates [(RCC)2CuLi] to activated chromones. Unexpected formation of the 6H-bis[1]benzopyrano[2,3-b:3′,4′-e]pyridine system

Autor:	Christopher D. Gabbutt, Dan E. Daia, Malik. K. M. Abdul Malik. K. M. Abdul, B. Mark Heron, Michael B. Hursthouse, John D. Hepworth
Rok vydání:	2003
Předmět:	chemistry.chemical_compound chemistry Organic Chemistry Drug Discovery Pyridine chemistry.chemical_element Organic chemistry Lithium General Medicine Biochemistry Medicinal chemistry Conjugate
Zdroj:	Tetrahedron Letters. 44:1461-1464
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(02)02857-5
Popis:	Lithium dialkynylcuprates [(RCC)2CuLi], 1a–d, are easily generated and undergo conjugate additions to activated chromones giving 2-alkynylchroman-4-ones 4a–d, 13, 15c,d and 5, however, 1,4-additions to 3 proceed anomalously to give the eneynonitriles 6a–b and the bisbenzopyranopyridine 7.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::718bd3745afdef6d9c03f73cc88dce26 https://doi.org/10.1016/s0040-4039(02)02857-5 Zobrazit plný text záznamu Full Text from ScienceDirect