Adding marrow adiposity and cortical porosity to femoral neck areal bone mineral density improves the discrimination of women with nonvertebral fractures from controls

Autor: Marit Osima, Peter R. Ebeling, Marko Lukic, Xiaofang Wang, Ali Ghasem-Zadeh, Angela Vais, Åshild Bjørnerem, Erik Fink Eriksen, Ego Seeman, Catherine Shore-Lorenti, Roger Zebaze, Minh Bui
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Adult
0301 basic medicine
medicine.medical_specialty
Bone density
Endocrinology
Diabetes and Metabolism
Osteoporosis
Urology
030209 endocrinology & metabolism
Fractures
Bone
03 medical and health sciences
0302 clinical medicine
Cortical porosity
Bone Density
Bone Marrow
medicine
Humans
Orthopedics and Sports Medicine
Prospective cohort study
cortical porosity
marrow adiposity
Adiposity
Aged
Femoral neck
Bone mineral
VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin
sosialmedisin: 801
Femur Neck
business.industry
Australia
hr‐pqct
Odds ratio
Middle Aged
medicine.disease
030104 developmental biology
medicine.anatomical_structure
Female
Bone marrow
women
VDP::Medical disciplines: 700::Health sciences: 800::Community medicine
Social medicine: 801
business
Porosity
nonvertebral fracture
ISSN: 1451-1460
0884-0431
Popis: This is the peer reviewed version of the following article: Zebaze, R., Osima, M., Bui, M., Lukic, M., Wang, X., Ghasem-Zadeh, A. ... Bjørnerem, Å. (2019). Adding marrow adiposity and cortical porosity to femoral neck areal bone mineral density improves the discrimination of women with nonvertebral fractures from controls. Journal of Bone and Mineral Research, 34(8), 1451-1460, which has been published in final form at https://doi.org/10.1002/jbmr.3721. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Advancing age is accompanied by a reduction in bone formation and remodeling imbalance, which produces microstructural deterioration. This may be partly caused by a diversion of mesenchymal cells towards adipocytes rather than osteoblast lineage cells. We hypothesized that microstructural deterioration would be associated with an increased marrow adiposity, and each of these traits would be independently associated with nonvertebral fractures and improve discrimination of women with fractures from controls over that achieved by femoral neck (FN) areal bone mineral density (aBMD) alone. The marrow adiposity and bone microstructure were quantified from HR‐pQCT images of the distal tibia and distal radius in 77 women aged 40 to 70 years with a recent nonvertebral fracture and 226 controls in Melbourne, Australia. Marrow fat measurement from HR‐pQCT images was validated using direct histologic measurement as the gold standard, at the distal radius of 15 sheep, with an agreement (R2 = 0.86, p p p = 0.006) or marrow adiposity was added to FN aBMD and age (AUC 0.825 versus 0.751, p = 0.002). The model including FN aBMD, age, cortical porosity, trabecular thickness, and marrow adiposity had an AUC = 0.888. Results were similar for the distal radius. Whether marrow adiposity and cortical porosity indices improve the identification of women at risk for fractures requires validation in prospective studies.
Databáze: OpenAIRE
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