Hepatocyte Growth Factor Production may be Related to the Inflammatory Response in Patients With Acute Myocardial Infarction
| Autor: | Kazuhide Takeuchi, Yoshihisa Shimada, Kimio Kamimori, Minoru Yoshiyama, Junichi Yoshikawa, Hidetaka Iida, Yasuhiro Nakamura, Satoshi Jissho |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Myocardial Infarction Inflammation Coronary Angiography Internal medicine medicine Humans Angina Unstable Myocardial infarction Aged Analysis of Variance Neovascularization Pathologic biology Hepatocyte Growth Factor business.industry Unstable angina C-reactive protein General Medicine Heparin Middle Aged medicine.disease Coronary Vessels C-Reactive Protein Endocrinology Case-Control Studies biology.protein Hepatocyte growth factor production Female Hepatocyte growth factor Creatine kinase medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Circulation Journal. 66:253-256 |
| ISSN: | 1347-4820 1346-9843 |
| DOI: | 10.1253/circj.66.253 |
| Popis: | Hepatocyte growth factor (HGF) is a well-known powerful proliferative factor of vascular endothelial cells and it has been reported that plasma HGF concentrations are increased in acute myocardial infarction (AMI), although the mechanisms are not yet well delineated. Serum HGF levels and C-reactive protein (CRP) were measured in 22 patients with unstable angina pectoris (UAP) (15 males, 7 females; class IIb or IIIb of the Braunwald classification), 60 patients with AMI (37 males, 23 females; average time from the onset of symptoms to admission 4.6±0.7 h, range, 0.5-12 h), and 20 normal subjects. Immediate angioplasties were performed in 51 patients with AMI, and the time course of the HGF levels were measured in 31 patients among them. Heparin dramatically increased the HGF level and it declined to the normal range 18 h after heparin injection. Blood samples were taken before heparin treatment, or at least 24 h after. Serum HGF levels on admission was significantly increased in UAP (mean ± SE: 0.30±0.03 ng/ml, p |
| Databáze: | OpenAIRE |
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