Predominance of HIV-1 subtype A and D infections in Uganda
| Autor: | Sylvester D.K. Sempala, Robert Downing, Renu B. Lal, James Baggs, Jonathan Dorn, Benon Biryahwaho, Dale J. Hu, Danuta Pieniazek, Mark A. Rayfield, Carol Fridlund, Timothy J. Dondero |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Prevalence Human immunodeficiency virus (HIV) lcsh:Medicine Biology Gp41 medicine.disease_cause Virus lcsh:Infectious and parasitic diseases Phylogenetics medicine Humans lcsh:RC109-216 Uganda Phylogeny Genetic diversity Acquired Immunodeficiency Syndrome Phylogenetic tree Molecular epidemiology lcsh:R virus diseases Virology Immunology HIV-1 subtype D Female subtype A Research Article |
| Zdroj: | Emerging Infectious Diseases Emerging Infectious Diseases, Vol 6, Iss 6, Pp 509-515 (2000) |
| ISSN: | 1080-6040 |
| Popis: | To better characterize the virus isolates associated with the HIV-1 epidemic in Uganda, 100 specimens from HIV-1-infected persons were randomly selected from each of two periods from late 1994 to late 1997. The 200 specimens were classified into HIV-1 subtypes by sequence-based phylogenetic analysis of the envelope (env) gp41 region; 98 (49%) were classified as env subtype A, 96 (48%) as D, 5 (2.5%) as C, and 1 was not classified as a known env subtype. Demographic characteristics of persons infected with the two principal HIV-1 subtypes, A and D, were very similar, and the proportion of either subtype did not differ significantly between early and later periods. Our systematic characterization of the HIV-1 epidemic in Uganda over an almost 3-year period documented that the distribution and degree of genetic diversity of the HIV subtypes A and D are very similar and have not changed appreciably over that time. |
| Databáze: | OpenAIRE |
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