Chemotherapeutic drug-specific alteration of microvascular blood flow in murine breast cancer as measured by diffuse correlation spectroscopy
| Autor: | Tong Tong Wu, Turgut Durduran, Songfeng Han, Gabriel A. Ramirez, Ashley R. Proctor, Russell R. Adams, Kelley S. Madden, Parisa Farzam, Thomas H. Foster, Daniel K. Byun, Jingxuan Ren, Ki Won Jung, Regine Choe, Edward B. Brown |
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| Přispěvatelé: | Universitat Politècnica de Catalunya. Institut de Ciències Fotòniques |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty spectroscopy Cyclophosphamide medicine.medical_treatment 01 natural sciences Article 010309 optics 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Breast cancer In vivo 0103 physical sciences Medicine Doxorubicin Chemotherapy medicine.diagnostic_test Física [Àrees temàtiques de la UPC] business.industry Magnetic resonance imaging Blood flow Òptica medicine.disease Atomic and Molecular Physics and Optics Paclitaxel chemistry 030220 oncology & carcinogenesis Medical optics and biotechnology business Biotechnology medicine.drug |
| Zdroj: | UPCommons. Portal del coneixement obert de la UPC Universitat Politècnica de Catalunya (UPC) Recercat. Dipósit de la Recerca de Catalunya instname |
| Popis: | The non-invasive, in vivo measurement of microvascular blood flow has the potential to enhance breast cancer therapy monitoring. Here, longitudinal blood flow of 4T1 murine breast cancer (N=125) under chemotherapy was quantified with diffuse correlation spectroscopy based on layer models. Six different treatment regimens involving doxorubicin, cyclophosphamide, and paclitaxel at clinically relevant doses were investigated. Treatments with cyclophosphamide increased blood flow as early as 3 days after administration, whereas paclitaxel induced a transient blood flow decrease at 1 day after administration. Early blood flow changes correlated strongly with the treatment outcome and distinguished treated from untreated mice individually for effective treatments. |
| Databáze: | OpenAIRE |
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