Skin score correlates with global DNA methylation and GSTO1 A140D polymorphism in arsenic-affected population of Eastern India
| Autor: | Nilansu Das, D N Guha Mazumder, Uma B Dasgupta, Moumita Majumder |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Health Toxicology and Mutagenesis Population chemistry.chemical_element India Biology Toxicology Genome Polymorphism Single Nucleotide Severity of Illness Index Skin Diseases Arsenic 03 medical and health sciences chemistry.chemical_compound Humans education Gene Glutathione Transferase Genetics education.field_of_study integumentary system Arsenic toxicity Glutathione DNA Methylation 030104 developmental biology chemistry DNA methylation Female Water Pollutants Chemical Toxicant |
| Zdroj: | Toxicology mechanisms and methods. 27(6) |
| ISSN: | 1537-6524 |
| Popis: | Arsenic is a potent environmental toxicant causing serious public health concerns in India, Bangladesh and other parts of the world. Gene- and promoter-specific hypermethylation has been reported in different arsenic-exposed cell lines, whereas whole genome DNA methylation study suggested genomic hypo- and hypermethylation after arsenic exposure in in vitro and in vivo studies. Along with other characteristic biomarkers, arsenic toxicity leads to typical skin lesions. The present study demonstrates significant correlation between severities of skin manifestations with their whole genome DNA methylation status as well as with a particular polymorphism (Ala 140 Asp) status in arsenic metabolizing enzyme Glutathione S-transferase Omega-1 (GSTO1) in arsenic-exposed population of the district of Nadia, West Bengal, India. |
| Databáze: | OpenAIRE |
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