Klyflaccisteroids K-M, bioactive steroidal derivatives from a soft coral Klyxum flaccidum
| Autor: | Ping-Jyun Sung, Chiung-Yao Huang, Pei-Lun Chiang, Tsong-Long Hwang, Wan-Ru Tseng, Jyh-Horng Sheu, Yi-Ying Tsai, Jui-Hsin Su, Chang-Feng Dai |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Stereochemistry
Cell Survival Neutrophils Coral medicine.medical_treatment Clinical Biochemistry Anti-Inflammatory Agents Pharmaceutical Science 01 natural sciences Biochemistry Steroid chemistry.chemical_compound Inhibitory Concentration 50 Superoxides Cell Line Tumor Drug Discovery medicine Animals Humans Cytotoxicity Molecular Biology 010405 organic chemistry Superoxide Organic Chemistry Elastase Anthozoa 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Cancer cell Molecular Medicine Steroids Klyxum flaccidum |
| Zdroj: | Bioorganicmedicinal chemistry letters. 27(5) |
| ISSN: | 1464-3405 |
| Popis: | New steroids, klyflaccisteroids K-M (1-3), were isolated from a soft coral Klyxum flaccidum. Their structures were elucidated on the basis of extensive spectroscopic analysis. Klyflaccisteroid K (1) is the unique 9,11-secosteroid with a 5,8-epidioxy-9-ene functional group. Klyflaccisteroid L (2) has an unusual 11-norsteroid skeleton and is the first example of 11-oxasteroid isolated from natural sources. Cytotoxicity assay showed that 1 and 3 possessed moderate to weak cytotoxicity against these cancer cells. Compound 1 was also found to display significant anti-inflammatory activity of suppressing superoxide anion generation (O2-) and elastase release, and compound 3 was found to show notable anti-inflammatory activity toward inhibition of elasstase release, too. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect