Interleukin-12 Is Associated With Arterial Stiffness in Healthy Individuals
| Autor: | Wai H. Lim, Neil Boudville, Ee Mun Lim, Helena Ching, Gursharan Dogra, Doris Chan, Kenneth Yong, Leon A. Adams |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Inflammation Pulse Wave Analysis Proinflammatory cytokine Vascular Stiffness Risk Factors Internal medicine Internal Medicine medicine Humans Pulse wave velocity business.industry Interleukin-18 Middle Aged Atherosclerosis medicine.disease Interleukin-12 Cross-Sectional Studies Blood pressure Cardiology Arterial stiffness Regression Analysis Female Interleukin 18 Animal studies medicine.symptom business Biomarkers Lipoprotein |
| Zdroj: | American Journal of Hypertension. 26:159-162 |
| ISSN: | 1941-7225 0895-7061 |
| Popis: | BACKGROUND Atherosclerotic cardiovascular disease (CVD) is a chronic inflammatory disease mediated by the proinflammatory cytokines interleukin-12 (IL-12) and interleukin-18 (IL-18). Evidence suggests that IL-12 is dominant in early atherosclerosis, while IL-18 is critical in advanced atherosclerosis. In this study, we explore the association between IL-12 and IL-18 and arterial stiffness in healthy individuals. METHODS We performed a cross-sectional study examining pulse wave velocity (PWV), augmentation index (AIx), IL-12, and IL-18 in healthy individuals (N = 53) without CVD risk factors. RESULTS In multivariate regression, age (P < 0.01), systolic blood pressure (P = 0.05), and IL-12 (P < 0.01) were positively associated with PWV, and high-density lipoprotein (P = 0.04) was negatively associated with PWV (model R (2) = 0.476, P < 0.01). CONCLUSIONS IL-12, but not IL-18, is associated with PWV in healthy individuals without clinical CVD, supporting a role for IL-12 in early atherosclerosis as suggested by animal studies. |
| Databáze: | OpenAIRE |
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