Quercetin, but Not Epicatechin, Decreases Plasma Concentrations of Methylglyoxal in Adults in a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial with Pure Flavonoids
| Autor: | Coen D.A. Stehouwer, Johanna M. Geleijnse, Lydia A. Afman, Nordin M J Hanssen, Mathias D G Van den Eynde, James I Dower, Peter C. H. Hollman, Jean L.J.M. Scheijen, Casper G. Schalkwijk |
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| Přispěvatelé: | Promovendi CD, Interne Geneeskunde, RS: CARIM - R3.01 - Vascular complications of diabetes and the metabolic syndrome, MUMC+: MA Alg Onderzoek Interne Geneeskunde (9), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), MUMC+: HVC Pieken Maastricht Studie (9), MUMC+: MA Interne Geneeskunde (3) |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Nutrition and Disease Medicine (miscellaneous) Catechin SERUM-ALBUMIN quercetin Voeding Metabolisme en Genomica chemistry.chemical_compound Lactoylglutathione lyase ANTIGLYCATION ACTIVITY 0302 clinical medicine (pre)hypertension Glycation Voeding en Ziekte methylglyoxal intervention Human Nutrition & Health Epicatechin STRUCTURAL REQUIREMENTS Cross-Over Studies Nutrition and Dietetics biology Humane Voeding & Gezondheid Methylglyoxal Advanced glycation endproducts clinical trial Middle Aged Pyruvaldehyde Metabolism and Genomics Clinical trial CARDIOVASCULAR-DISEASE Metabolisme en Genomica Female Nutrition Metabolism and Genomics Quercetin GLYCATION END-PRODUCTS advanced glycation endproducts Adult medicine.medical_specialty Serum albumin 030209 endocrinology & metabolism Intervention DARK CHOCOLATE DIETARY POLYPHENOLS Placebo glyoxalase 1 03 medical and health sciences Double-Blind Method Voeding Internal medicine Diabetes mellitus medicine Humans Aged Nutrition VLAG Flavonoids epicatechin medicine.disease Crossover study 030104 developmental biology Endocrinology chemistry Glyoxalase 1 flavonoids ENDOTHELIAL DYSFUNCTION biology.protein VASCULAR FUNCTION TRAPPING METHYLGLYOXAL |
| Zdroj: | Journal of Nutrition 148 (2018) 12 Journal of Nutrition, 148(12), 1911-1916 Journal of Nutrition, 148(12), 1911-1916. Oxford University Press |
| ISSN: | 0022-3166 1911-1916 |
| Popis: | Background: Methylglyoxal (MGO) is the most potent precursor of advanced glycation end products (AGEs). MGO and AGEs have been associated with diabetes, its complications, and other age-related diseases. Experimental studies have shown that the flavonoids quercetin and epicatechin are able to scavenge MGO and lower AGE formation.Objective: Data on the effects of these flavonoids on MGO and AGE concentrations in humans are not yet available. We therefore investigated the effect of quercetin and epicatechin on the concentrations of MGO and AGEs in a post hoc analysis.Methods: Thirty-seven apparently healthy, nonsmoking adults with a systolic blood pressure between 125 and 160 mm Hg at screening were included in a randomized, double-blind, placebo-controlled crossover trial. Participants ingested (-)-epicatechin (100 mg/d), quercetin 3-glucoside (160 mg/d), or placebo capsules for periods of 4 wk separated by 4-wk washout periods. Fasting blood samples were collected at the start and end of each intervention period. Liquid chromatography-tandem mass spectrometry was used to determine plasma concentrations of the dicarbonyl compounds MGO, glyoxal (GO), and 3-deoxyglucosone (3-DG) and free and protein-bound AGEs. Gene expression of glyoxalase 1 (GLO1), the enzyme involved in the degradation of MGO, was determined by either microarray or quantitative reverse transcriptase-polymerase chain reaction.Results: The treatment effect (Delta treatment - Delta placebo) of quercetin on MGO was -40.2 nmol/L (95% CI: -73.6, -6.8 nmol/L; P = 0.019), a decrease of 11% from baseline values, whereas GO, 3-DG, and free and protein-bound AGEs did not change significantly. Epicatechin did not affect the concentrations of dicarbonyls and free and protein-bound AGEs. We did not find a significant change in expression of GLO1.Conclusions: In apparently healthy (pre)hypertensive men and women, quercetin but not epicatechin decreased plasma MGO concentrations. Quercetin may potentially form a new treatment strategy for diseases in which MGO plays a pivotal role. |
| Databáze: | OpenAIRE |
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