Erythrocytes as Carriers: From Drug Delivery to Biosensors
| Autor: | Elizaveta Bovt, Elena I. Sinauridze, Larisa Koleva, Fazoil I. Ataullakhanov |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Drug
Proteases medicine.drug_class media_common.quotation_subject Antibiotics Pharmaceutical Science lcsh:RS1-441 Review Pharmacology targeted drug delivery lcsh:Pharmacy and materia medica 03 medical and health sciences 0302 clinical medicine Immune system erythrocyte-bioreactor In vivo medicine diagnostics 030304 developmental biology media_common 0303 health sciences therapy Chemistry carrier erythrocyte Mononuclear phagocyte system Targeted drug delivery 030220 oncology & carcinogenesis Drug delivery drug delivery erythrocyte |
| Zdroj: | Pharmaceutics, Vol 12, Iss 3, p 276 (2020) Pharmaceutics |
| ISSN: | 1999-4923 |
| Popis: | Drug delivery using natural biological carriers, especially erythrocytes, is a rapidly developing field. Such erythrocytes can act as carriers that prolong the drug’s action due to its gradual release from the carrier; as bioreactors with encapsulated enzymes performing the necessary reactions, while remaining inaccessible to the immune system and plasma proteases; or as a tool for targeted drug delivery to target organs, primarily to cells of the reticuloendothelial system, liver and spleen. To date, erythrocytes have been studied as carriers for a wide range of drugs, such as enzymes, antibiotics, anti-inflammatory, antiviral drugs, etc., and for diagnostic purposes (e.g., magnetic resonance imaging). The review focuses only on drugs loaded inside erythrocytes, defines the main lines of research for erythrocytes with bioactive substances, as well as the advantages and limitations of their application. Particular attention is paid to in vivo studies, opening-up the potential for the clinical use of drugs encapsulated into erythrocytes. |
| Databáze: | OpenAIRE |
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