| Autor: |
Vitezslav Bryja, Sarka Pavlova, Sarka Pospisilova, Alois Kozubik, Sivasubramanian Baskar, Michaela Machalova, Michael Doubek, Yvona Brychtova, Olga Stehlikova, Marek Borsky, Michaela Hlozkova, Petra Ovesna, Marketa Kaucka, Martin Behal, Hana Plesingerova, Karla Plevova, Lucie Poppova, Pavlina Janovska |
| Rok vydání: |
2023 |
| Popis: |
Supplementary Figures 1-6. Supplementary Fig. 1: ROR1 mRNA expression determined by qRT-PCR correlates with the amount of the surface receptor present on primary CLL cells. Supplementary Fig. 2: Expression of ROR1 in the WNT5A-negative and WNT5Apositive(A), and WNT5B-low and WNT5B-high (B) patient cohorts. Supplementary Fig. 3: A-C) Time-to-first treatment (TTFT) of patient groups stratified based on the expression of WNT5 genes was plotted using Kaplan-Meier survival curves. Supplementary Fig. 4: Expression of WNT5B mRNA levels in patients with TP53 mutations. n.s. - not significant (Mann-Whitney test). Supplementary Fig. 5: A) - C) Expression of surface receptors ROR1, CXCR4 and CCR7 was evaluated by vital staining and flow-cytometry (N=14). Supplementary Fig. 6: Freshly isolated CLL cells were treated as indicated and their migration was analysed using the Transwell assays. Supplementary Materials and Methods |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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