The Cancer Genome Atlas (TCGA) based m6A methylation-related genes predict prognosis in hepatocellular carcinoma
| Autor: | Gui-Li Sun, Zhongzhuan Li, Mengbin Qin, Rong Ouyang, Jie-An Huang, Jun Liu, Shang-Ling Pan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Carcinoma Hepatocellular Bioengineering Biology Applied Microbiology and Biotechnology n6-methyladenosine methylation 03 medical and health sciences Clinical prognosis 0302 clinical medicine Atlas (anatomy) Cancer genome Biomarkers Tumor medicine Humans tcga Gene Proportional Hazards Models Liver Neoplasms Computational Biology RNA-Binding Proteins Methyltransferases General Medicine Methylation hepatocellular carcinoma Prognosis medicine.disease digestive system diseases Gene Expression Regulation Neoplastic 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Hepatocellular carcinoma Cancer research Female TP248.13-248.65 Research Article Research Paper Biotechnology |
| Zdroj: | Bioengineered, Vol 11, Iss 1, Pp 759-768 (2020) Bioengineered article-version (VoR) Version of Record |
| ISSN: | 2165-5987 2165-5979 |
| Popis: | The current study aims to investigate the significance of N6-methyladenosine (m6A) methylation-related genes in the clinical prognosis of hepatocellular carcinoma (HCC) using bioinformatics analyses based on The Cancer Genome Atlas (TCGA) database. Transcriptome data and corresponding clinical data on m6A methylation-related genes (including 15 genes) were obtained from TCGA database. Differential expression of 15 genes was identified. Survival curves of subgroups based on m6A methylation-related gene expression levels were plotted. We selected potential predictive genes and analyzed their prognostic values using bioinformatics methods. Eleven genes (METTL3, YTHDF1, YTHDF2, YTHDF3, YTHDC1, YTHDC2, FTO, KIAA1429, HNRNPC, HNRNPA2B1, and RBM15) were found to be overexpressed in HCC. Of these, five genes had worse survival (P Graphical abstract |
| Databáze: | OpenAIRE |
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