Effect of Gomisin A in the Prevention of Acute Hepatic Failure Induction
| Autor: | Norifumi Kawada, Yuzo Ichikawa, Yasuhiro Mizoguchi, Hiroko Tsutsui |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Schisandra chinensis Pharmaceutical Science Dioxoles Pharmacology Lignans Analytical Chemistry Liver disorder Cyclooctanes chemistry.chemical_compound Oral administration Drug Discovery Splenocyte Animals Medicine Polycyclic Compounds Propionibacterium acnes Transaminases biology business.industry Liver Diseases Pokeweed mitogen Organic Chemistry Interleukin Rats Inbred Strains biology.organism_classification Diet Rats Complementary and alternative medicine chemistry Immunology Gomisin A Hepatic stellate cell Molecular Medicine business Spleen Interleukin-1 |
| Zdroj: | Planta Medica. 57:320-324 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-2006-960107 |
| Popis: | Nearly all rats develop massive hepatic cell necrosis and die upon intravenous administration of heat-killed Propionibacterium acnes followed by a small amount of Gram-negative lipopolysaccharide 7 days later. However, when such an experimental liver disorder is induced in rats raised for 4 or more weeks on food containing 0.06% of gomisin A extracted and purified from Schizandra chinensis, the survival rate rises, histological changes of the liver improve remarkably, and splenocyte reactivity to phytohemagglutinin and pokeweed mitogen as well as splenocyte interleukin 1 productivity are retained. These results suggested the possibility that the development of acute hepatic failure may be prevented with the oral administration of gomisin A. |
| Databáze: | OpenAIRE |
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