Continuous and precise particle separation by electroosmotic flow control in microfluidic devices
| Autor: | Masahiro Yasuda, Masumi Yamada, Takahiro Kawamata, Minoru Seki |
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| Rok vydání: | 2008 |
| Předmět: |
geography
geography.geographical_feature_category Microchannel Chemistry Microfluidics Clinical Biochemistry Analytical chemistry Reproducibility of Results Electro-osmosis Mechanics Models Theoretical Inlet Biochemistry Analytical Chemistry Volumetric flow rate Flow control (fluid) Miniaturization Voltage |
| Zdroj: | ELECTROPHORESIS. 29:1423-1430 |
| ISSN: | 1522-2683 0173-0835 |
| DOI: | 10.1002/elps.200700658 |
| Popis: | A new scheme has been described for continuous particle separation using EOF in microfluidic devices. We have previously reported a method for particle separation, called "pinched flow fractionation (PFF)", in which size-dependent and continuous particle separation can be achieved by introducing pressure-driven flows with and without particles into a pinched microchannel. In this study, EOF was employed to transport fluid flows inside a microchannel. By controlling the applied voltage to electrodes inserted in each inlet/outlet port, the flow rates from both inlets, and flow rates distributed to each outlet could be accurately tuned, thus enabling more effective separation compared to the pressure-driven scheme. In the experiment, the particle behaviors were compared between EOF and pressure-driven flow schemes. In addition, micrometer- and submicrometer-sized particles were accurately separated and individually collected using a microchannel with multiple outlet branch channels, demonstrating the high efficiency of the presented scheme. |
| Databáze: | OpenAIRE |
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