Tumor suppressor TNFAIP3 (A20) is frequently deleted in Sézary syndrome
| Autor: | Piotr Grabarczyk, M Beyer, J Eberle, Markus Möbs, Frank K. Braun, F C M Braun, F Busse, Christian A. Schmidt, Martin Delin, Grzegorz K. Przybylski, J Schröder, Wolfram Sterry |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Cancer Research Skin Neoplasms CD30 T-Lymphocytes Blotting Western Biology Lymphocyte Activation TNFAIP3 law.invention immune system diseases law hemic and lymphatic diseases Tumor Cells Cultured Humans Sezary Syndrome Genes Tumor Suppressor RNA Messenger RNA Small Interfering Tumor Necrosis Factor alpha-Induced Protein 3 Aged Aged 80 and over Comparative Genomic Hybridization Reverse Transcriptase Polymerase Chain Reaction Cell Cycle Intracellular Signaling Peptides and Proteins NF-kappa B Nuclear Proteins Hematology DNA Methylation Middle Aged Cell cycle DNA-Binding Proteins Oncology Cell culture Immunology DNA methylation Suppressor Female Tumor necrosis factor alpha Gene Deletion |
| Zdroj: | Leukemia. 25:1494-1501 |
| ISSN: | 1476-5551 0887-6924 |
| DOI: | 10.1038/leu.2011.101 |
| Popis: | Despite recent therapeutic improvements, the prognosis for patients suffering from Sézary syndrome (SS), a disseminated form of cutaneous T-cell lymphomas, is still poor. We identified bi- and monoallelic deletions of the tumor necrosis factor-α-induced protein 3 gene (TNFAIP3; A20) in a high proportion of SS patients as well as biallelic A20 deletion in the SS-derived cell line SeAx. Furthermore, we demonstrate that inhibition of A20 activates the NF-κB pathway thereby increasing the proliferation of normal T lymphocytes. On the other hand, the reconstitution of A20 expression slowed down the cell cycle in SeAx cells. Recently A20 inactivation has been reported in various B-cell lymphomas. In this study, we show that A20 is also a putative tumor suppressor in the T-cell malignancy-SS. |
| Databáze: | OpenAIRE |
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