Synthesis, characterization, and antibacterial activity of novel Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes with vitamin K3-thiosemicarbazone
| Autor: | Liu-Fang Wang, Hui-an Tang, Chun-Gu Xia, Qin-Xi Li, Min Wang, Yi-Zhi Li |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Thiosemicarbazones
Staphylococcus aureus Vitamin K Molar conductivity Bacillus Microbial Sensitivity Tests Crystal structure Ligands Biochemistry Complexometric titration Inorganic Chemistry Metal chemistry.chemical_compound Transition metal Escherichia coli Semicarbazone Schiff base Molecular Structure Ligand Anti-Bacterial Agents Crystallography chemistry Metals visual_art visual_art.visual_art_medium Nuclear chemistry |
| Zdroj: | Journal of Inorganic Biochemistry. 78:167-174 |
| ISSN: | 0162-0134 |
| DOI: | 10.1016/s0162-0134(99)00226-3 |
| Popis: | Vitamin K-3-thiosemicarbazone (C12H11N3NaO4S2. 5H(2)O, abbreviated as VT), a new Schiff base derivative, has been synthesized. Its crystal structure, determined by X-ray diffraction, is triclinic, space group P (1) over bar. We have also prepared five novel complexes of VT with transition metals: [M(VT)(2)2H(2)O]. nH(2)O, (n = 1 and 2 for M = Cu(n) and Zn(II), respectively) and [M'(HVT)(2)Cl-2]. mH2O, (m =4, 5, and 7 for M' =Co(II), Mn(II), and Ni(n), respectively). These compounds were characterized by IR and UV-Vis spectroscopy, molar conductivity, thermal analyses, complexometric titration, and elemental analysis. In all the complexes, the VT ligand coordinates through sulfur and oxygen atoms, and the geometry around metal atom is best described as octahedral, in vitro tests of antibacterial activity showed that VT and its complexes with Mn(II), Co(n),Ni(II), Cu(II), and Zn(II) all had strong inhibitory actions against G(+) Staphylococcus aureus, G(+) Hay bacillus, and G(-) Escherichia coli. (C) 2000 Elsevier Science Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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