Effects of captopril on hemodynamics and blood gases in chronic obstructive lung disease with pulmonary hypertension
| Autor: | Ines Busnardo, G. Rizzato, Guido Montanari, Livio Bertoli, Salvatore Lo Cicero |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty Pulmonary Circulation Captopril Hypertension Pulmonary Hemodynamics Blood Pressure Internal medicine Medicine Humans Lung Diseases Obstructive Pulmonary Wedge Pressure Cardiac Output Pulmonary wedge pressure Aged business.industry Pulmonary Gas Exchange Respiratory disease Middle Aged medicine.disease Pulmonary hypertension Obstructive lung disease medicine.anatomical_structure Blood pressure Vascular resistance Cardiology Vascular Resistance business medicine.drug |
| Zdroj: | Respiration; international review of thoracic diseases. 49(4) |
| ISSN: | 0025-7931 |
| Popis: | The effects of Captopril, an angiotensin-converting enzyme inhibitor, on pulmonary hemodynamics and blood gases were studied in 9 patients with chronic obstructive lung disease (COLD) and pulmonary hypertension (PA-P greater than 20 mm Hg). Hemodynamic data were recorded prior to Captopril administration (50 mg per os) and for the next 60 min. Following Captopril administration, significant reductions in mean pulmonary artery pressure (PA-P) (p less than 0.05), in mean pulmonary wedge pressure (PW-P) (p less than 0.05), and in total pulmonary resistance (TPR) were noted; significant reductions in mean brachial artery pressure (BA-P) and systemic vascular resistance (SVR) were also recorded, while cardiac output, heart rate and blood gas tensions showed no significant changes. Furthermore, the higher the hypoxemia, the greater was the reduction in BA-P (p less than 0.05). We therefore feel that Captopril, when administered to COLD patients with pulmonary hypertension, may protect the pulmonary circulation from hypoxic pulmonary vasoconstriction. |
| Databáze: | OpenAIRE |
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