Histopathologic reaction patterns to differentially cross‐linked hyaluronic acid fillers: A retrospective case series
| Autor: | Evan Stokar, Shane A Meehan, Euphemia W. Mu, Linda Franks |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Filler (packaging) Pathology medicine.medical_specialty Histology Drug-Related Side Effects and Adverse Reactions Biopsy Dermatology Pathology and Forensic Medicine 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Dermal Fillers Hyaluronic acid Humans Medicine Hyaluronic Acid Histiocyte Aged Retrospective Studies Aged 80 and over Inflammation Viscosupplements Manufacturing process business.industry Histiocytes Middle Aged Eosinophilic Granuloma Eosinophils chemistry 030220 oncology & carcinogenesis Female Electronic database Dermatopathology business |
| Zdroj: | Journal of Cutaneous Pathology. 48:758-762 |
| ISSN: | 1600-0560 0303-6987 |
| DOI: | 10.1111/cup.13947 |
| Popis: | BACKGROUND Hyaluronic acid filler reactions have been increasingly observed in recent years. Our study investigates whether the increased number of filler reactions observed since 2014 is associated with a specific histopathologic inflammatory pattern and type of filler. METHODS The institution's dermatopathology electronic database was retrospectively searched for histopathologic reactions to hyaluronic acid from January 2014 to December 2019. The age, sex, type of filler, procedure, location, and histopathologic patterns were recorded. RESULTS From 2014 to 2019, there were 15 cases of granulomatous reactions to hyaluronic acid filler. In 10 of these cases, there was a characteristic inflammatory pattern characterized by tightly cuffed palisades of histiocytes with varying numbers of eosinophils. Of the 11 cases in which the type of filler was known, all used Vycross technology, a novel manufacturing process in the production of hyaluronic acid filler. CONCLUSION A characteristic histopathologic pattern of discrete foci of tightly cuffed palisaded granulomas with eosinophils is associated with fillers manufactured using Vycross technology. |
| Databáze: | OpenAIRE |
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