Small Proteins; Big Questions
| Autor: | Gisela Storz, Kai Papenfort, Todd A. Gray |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
chemistry.chemical_classification
0303 health sciences Bacteria 030306 microbiology Gene Expression Regulation Bacterial Computational biology Biology biology.organism_classification Meeting Review Microbiology Amino acid Open Reading Frames 03 medical and health sciences Bacterial Proteins chemistry Amino Acid Sequence Ribosome profiling Molecular Biology Genome Bacterial 030304 developmental biology Archaea |
| Zdroj: | J Bacteriol |
| ISSN: | 1098-5530 0021-9193 |
| DOI: | 10.1128/jb.00341-21 |
| Popis: | In recent years, there has been increased appreciation that a whole category of proteins, small proteins of around 50 amino acids or fewer in length, has been missed by annotation as well as by genetic and biochemical assays. With the increased recognition that small proteins are stable within cells and have regulatory functions, there has been intensified study of these proteins. As a result, important questions about small proteins in bacteria and archaea are coming to the fore. Here, we give an overview of these questions, the initial answers, and the approaches needed to address these questions more fully. More detailed discussions of how small proteins can be identified by ribosome profiling and mass spectrometry approaches are provided by two accompanying reviews (N. Vazquez-Laslop, C. M. Sharma, A. S. Mankin, and A. R. Buskirk, J Bacteriol 204:e00294-21, 2022, https://doi.org/10.1128/JB.00294-21; C. H. Ahrens, J. T. Wade, M. M. Champion, and J. D. Langer, J Bacteriol 204:e00353-21, 2022, https://doi.org/10.1128/JB.00353-21). We are excited by the prospects of new insights and possible therapeutic approaches coming from this emerging field. |
| Databáze: | OpenAIRE |
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