Immune activation and microbial translocation in liver disease progression in HIV/hepatitis co-infected patients: results from the Icona Foundation study
Autor: | Marchetti, Giulia, Cozzi Lepri, Alessandro, Tincati, Camilla, Calcagno, Andrea, Ceccherini Silberstein, Francesca, De Luca, Andrea, Antinori, Andrea, Castagna, Antonella, Puoti, Massimo, Monforte, Antonella d'Arminio, for the Icona Foundation Study Group […, Moroni M, Angarano G, Antinori A, Carosi G, Cauda R, Monforte A, Di Perri G, Galli M, Iardino R, Ippolito G, Lazzarin A, Perno CF, Viale PL, Von Schlosser F, Monforte Ad, Ammassari A, Andreoni M, Balotta C, Bonfanti P, Bonora S, Borderi M, Capobianchi MR, Castagna A, Ceccherini Silberstein F, Cozzi Lepri A, De Luca A, Gargiulo M, Gervasoni C, Girardi E, Lichtner M, Lo Caputo S, Madeddu G, Maggiolo F, Marcotullio S, Monno L, Murri R, Mussini C, Puoti M, Torti C, Fanti I, Formenti T, Montroni M, Giacometti A, Costantini A, Riva A, Tirelli U, Martellotta F, Ladisa N, Suter F, Piergentili B, Cristini G, Minardi C, Bertelli D, Quirino T, Abeli C, Manconi PE, Piano P, Vecchiet J, Falasca K, Carnevale G, Lorenzotti S, Sighinolfi L, Leoncini F, Mazzotta F, Pozzi M, Cassola G, Viscoli G, Alessandrini A, Piscopo R, Mazzarello G, Mastroianni C, Belvisi V, Molteni C, Chiodera A, Castelli P, Rizzardini G, Ridolfo AL, Foschi A, Salpietro S, Merli S, Carenzi L, Moioli MC, Cicconi P, Esposito R, Gori A, Pastore V, Abrescia N, Chirianni A, De Marco M, Ferrari C, Borghi R, Baldelli F, Belfiori B, Parruti G, Sozio F, Magnani G, Ursitti MA, Arlotti M, Ortolani P, Antonucci G, Narciso P, Tozzi V, Vullo V, Zaccarelli M, Gallo L, Acinapura R, De Longis P, Ceccarelli L, Libertone R, Trotta MP, Miccoli A, Cattelan AM, Mura MS, Caramello P, Orofino GC, Sciandra M, Raise E, Ebo F, Pellizzer G, Buonfrate D, VERUCCHI, GABRIELLA |
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Přispěvatelé: | Marchetti, G, Cozzi Lepri, A, Tincati, C, Calcagno, A, Ceccherini Silberstein, F, DE LUCA, A, Antinori, A, Castagna, A, Puoti, M, Monforte, A, Marchetti, Giulia, Cozzi Lepri, Alessandro, Tincati, Camilla, Calcagno, Andrea, Ceccherini Silberstein, Francesca, De Luca, Andrea, Antinori, Andrea, Castagna, Antonella, Puoti, Massimo, Monforte Antonella, D'Arminio, Cozzi-Lepri, Alessandro, Ceccherini-Silberstein, Francesca, Monforte, Antonella d'Arminio, and for the Icona Foundation Study Group […, Moroni M, Angarano G, Antinori A, Carosi G, Cauda R, Monforte A, Di Perri G, Galli M, Iardino R, Ippolito G, Lazzarin A, Perno CF, Viale PL, Von Schlosser F, Monforte Ad, Ammassari A, Andreoni M, Balotta C, Bonfanti P, Bonora S, Borderi M, Capobianchi MR, Castagna A, Ceccherini-Silberstein F, Cozzi-Lepri A, De Luca A, Gargiulo M, Gervasoni C, Girardi E, Lichtner M, Lo Caputo S, Madeddu G, Maggiolo F, Marcotullio S, Monno L, Murri R, Mussini C, Puoti M, Torti C, Fanti I, Formenti T, Montroni M, Giacometti A, Costantini A, Riva A, Tirelli U, Martellotta F, Ladisa N, Suter F, Verucchi G, Piergentili B, Cristini G, Minardi C, Bertelli D, Quirino T, Abeli C, Manconi PE, Piano P, Vecchiet J, Falasca K, Carnevale G, Lorenzotti S, Sighinolfi L, Leoncini F, Mazzotta F, Pozzi M, Cassola G, Viscoli G, Alessandrini A, Piscopo R, Mazzarello G, Mastroianni C, Belvisi V, Molteni C, Chiodera A, Castelli P, Rizzardini G, Ridolfo AL, Foschi A, Salpietro S, Merli S, Carenzi L, Moioli MC, Cicconi P, Esposito R, Gori A, Pastore V, Abrescia N, Chirianni A, De Marco M, Ferrari C, Borghi R, Baldelli F, Belfiori B, Parruti G, Sozio F, Magnani G, Ursitti MA, Arlotti M, Ortolani P, Antonucci G, Narciso P, Tozzi V, Vullo V, Zaccarelli M, Gallo L, Acinapura R, De Longis P, Ceccarelli L, Libertone R, Trotta MP, Miccoli A, Cattelan AM, Mura MS, Caramello P, Orofino GC, Sciandra M, Raise E, Ebo F, Pellizzer G, Buonfrate D, …], DIPARTIMENTO DI SCIENZE MEDICHE E CHIRURGICHE, Facolta' di MEDICINA e CHIRURGIA, AREA MIN. 06 - Scienze mediche |
Jazyk: | angličtina |
Rok vydání: | 2014 |
Předmět: |
microbial
Male Fibrosi Lipopolysaccharide Receptors HIV Infections Kaplan-Meier Estimate Liver disease Medical microbiology Risk Factors HIV Infection Fib-4 Coinfection Liver Disease Medicine (all) Liver Diseases virus diseases Hepatitis A Hepatitis C Hepatitis B Middle Aged sCD14 Settore MED/07 - Microbiologia e Microbiologia Clinica Infectious Diseases Treatment Outcome HIV/hepatitis co-infection traslocation HCV HIV liver Disease Progression Biological Markers Female medicine.symptom Adult Antigens CD14 CD4 Lymphocyte Count Enzyme-Linked Immunosorbent Assay Fibrosis Humans Inflammation CD14 Microbial translocation Research Article Human medicine.medical_specialty Infectious Disease Settore MED/17 - MALATTIE INFETTIVE Biomarkers medicine Antigens Hepatitis business.industry Risk Factor Biomarker medicine.disease Virology digestive system diseases Immunology business |
Zdroj: | BMC Infectious Diseases |
Popis: | none 157 no Abstract BACKGROUND: We evaluated whether immune activation (IA) and microbial translocation (MT) might play a role in accelerating liver disease progression in HIV-HBV/HCV co-infected patients. METHODS: ART-naïve HIV/viral hepatitis co-infected patients from Icona with a CD4 cell count >200/μl and with a known date of prior HIV neg/pos tests and ≥1 plasma sample stored were included in the study. Plasma MT (LPS, sCD14) and IA (IL-6,TNFα) were measured using ELISA while activated CD8 + CD38 + HLA-DR + were measured by flow cytometry, with one measurement being performed for all patients and two measurements for a smaller group of subjects. The association between these biomarkers and the time to i) a single ALT >200 IU/l and ii) a Fib-4 >1.45 was also investigated. A standard survival analysis with robust standard errors was used for all evaluations. Follow-up was censored at patients' last clinical follow-up. RESULTS: We studied 127 HIV-infected hepatitis viruses co-infected patients (118 HCV, 9 HBV). Overall median (IQR) CD4, VL, age were 596/μl (208-1303), 3.8 log10cp/mL (3-4.3), 34 years (22-56). While heightened TNF-α was associated with a 13-fold increased risk of Fib-4 > 1.45 (RH 13.05, 95% CI 2.43-70; p = 0.003), markers of MT did not show an association with liver illness. Interestingly, higher sCD14 was associated with a decreased risk of Fib-4 > 1.45, independently of other biomarkers considered (RH 0.20, 95% CI 0.04-0,9; p = 0.04). CONCLUSIONS: In HIV/hepatitis virus co-infected ART-naive patients, higher TNF-α plasma levels were associated with a 13-fold increase in the risk of progression to a Fib-4 >1.45, suggesting that the pro-inflammatory status in HIV infection might hasten the course of HCV. In view of the fact that sCD14 may hinder the interaction between LPS and the phagocyte membrane CD14, we herewith propose a model which aims to demonstrate that high sCD14 levels might contribute to shelter liver function through the down-regulation of the inflammatory cascade. Marchetti, Giulia; Cozzi-Lepri, Alessandro; Tincati, Camilla; Calcagno, Andrea; Ceccherini-Silberstein, Francesca; De Luca, Andrea; Antinori, Andrea; Castagna, Antonella; Puoti, Massimo; Monforte, Antonella d'Arminio; and for the Icona Foundation Study Group […; Moroni M; Angarano G; Antinori A; Carosi G; Cauda R; Monforte A; Di Perri G; Galli M; Iardino R; Ippolito G; Lazzarin A; Perno CF; Viale PL; Von Schlosser F; Monforte Ad; Ammassari A; Andreoni M; Antinori A; Balotta C; Bonfanti P; Bonora S; Borderi M; Capobianchi MR; Castagna A; Ceccherini-Silberstein F; Cozzi-Lepri A; Monforte A; De Luca A; Gargiulo M; Gervasoni C; Girardi E; Lichtner M; Lo Caputo S; Madeddu G; Maggiolo F; Marcotullio S; Monno L; Murri R; Mussini C; Puoti M; Torti C; Cozzi-Lepri A; Fanti I; Formenti T; Montroni M; Giacometti A; Costantini A; Riva A; Tirelli U; Martellotta F; Angarano G; Monno L; Ladisa N; Suter F; Maggiolo F; Viale PL; Verucchi G; Piergentili B; Carosi G; Cristini G; Torti C; Minardi C; Bertelli D; Quirino T; Abeli C; Manconi PE; Piano P; Vecchiet J; Falasca K; Carnevale G; Lorenzotti S; Sighinolfi L; Leoncini F; Mazzotta F; Pozzi M; Lo Caputo S; Cassola G; Viscoli G; Alessandrini A; Piscopo R; Mazzarello G; Mastroianni C; Belvisi V; Bonfanti P; Molteni C; Chiodera A; Castelli P; Galli M; Lazzarin A; Rizzardini G; Puoti M; Monforte A; Ridolfo AL; Foschi A; Castagna A; Salpietro S; Merli S; Carenzi L; Moioli MC; Cicconi P; Formenti T; Esposito R; Mussini C; Gori A; Pastore V; Abrescia N; Chirianni A; De Marco M; Ferrari C; Borghi R; Baldelli F; Belfiori B; Parruti G; Sozio F; Magnani G; Ursitti MA; Arlotti M; Ortolani P; Cauda R; Andreoni M; Antinori A; Antonucci G; Narciso P; Tozzi V; Vullo V; De Luca A; Zaccarelli M; Gallo L; Acinapura R; De Longis P; Ceccarelli L; Libertone R; Trotta MP; Miccoli A; Cattelan AM; Mura MS; Madeddu G; Caramello P; Di Perri G; Orofino GC; Sciandra M; Raise E; Ebo F; Pellizzer G; Buonfrate D; …] Marchetti, Giulia; Cozzi-Lepri, Alessandro; Tincati, Camilla; Calcagno, Andrea; Ceccherini-Silberstein, Francesca; De Luca, Andrea; Antinori, Andrea; Castagna, Antonella; Puoti, Massimo; Monforte, Antonella d'Arminio; and for the Icona Foundation Study Group […; Moroni M; Angarano G; Antinori A; Carosi G; Cauda R; Monforte A; Di Perri G; Galli M; Iardino R; Ippolito G; Lazzarin A; Perno CF; Viale PL; Von Schlosser F; Monforte Ad; Ammassari A; Andreoni M; Antinori A; Balotta C; Bonfanti P; Bonora S; Borderi M; Capobianchi MR; Castagna A; Ceccherini-Silberstein F; Cozzi-Lepri A; Monforte A; De Luca A; Gargiulo M; Gervasoni C; Girardi E; Lichtner M; Lo Caputo S; Madeddu G; Maggiolo F; Marcotullio S; Monno L; Murri R; Mussini C; Puoti M; Torti C; Cozzi-Lepri A; Fanti I; Formenti T; Montroni M; Giacometti A; Costantini A; Riva A; Tirelli U; Martellotta F; Angarano G; Monno L; Ladisa N; Suter F; Maggiolo F; Viale PL; Verucchi G; Piergentili B; Carosi G; Cristini G; Torti C; Minardi C; Bertelli D; Quirino T; Abeli C; Manconi PE; Piano P; Vecchiet J; Falasca K; Carnevale G; Lorenzotti S; Sighinolfi L; Leoncini F; Mazzotta F; Pozzi M; Lo Caputo S; Cassola G; Viscoli G; Alessandrini A; Piscopo R; Mazzarello G; Mastroianni C; Belvisi V; Bonfanti P; Molteni C; Chiodera A; Castelli P; Galli M; Lazzarin A; Rizzardini G; Puoti M; Monforte A; Ridolfo AL; Foschi A; Castagna A; Salpietro S; Merli S; Carenzi L; Moioli MC; Cicconi P; Formenti T; Esposito R; Mussini C; Gori A; Pastore V; Abrescia N; Chirianni A; De Marco M; Ferrari C; Borghi R; Baldelli F; Belfiori B; Parruti G; Sozio F; Magnani G; Ursitti MA; Arlotti M; Ortolani P; Cauda R; Andreoni M; Antinori A; Antonucci G; Narciso P; Tozzi V; Vullo V; De Luca A; Zaccarelli M; Gallo L; Acinapura R; De Longis P; Ceccarelli L; Libertone R; Trotta MP; Miccoli A; Cattelan AM; Mura MS; Madeddu G; Caramello P; Di Perri G; Orofino GC; Sciandra M; Raise E; Ebo F; Pellizzer G; Buonfrate D; …] |
Databáze: | OpenAIRE |
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