VLA molecule expression may be involved in the release of acute myeloid leukaemic cells from the bone marrow
| Autor: | Ingrid A.M. Denkers, Mart M.A.C. Langenhuijsen, R.H.J. Beelen, Gert J. Ossenkoppele, Toni J.M. de Jong-de Boer |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Cancer Research
Myeloid Cell adhesion molecule business.industry Tris-buffered saline Hematology Pathogenesis chemistry.chemical_compound medicine.anatomical_structure Oncology chemistry Bone Marrow Leukemia Myeloid Receptors Very Late Antigen Acute Disease Immunology Gene expression medicine Cancer research Humans Liberation Neural cell adhesion molecule Bone marrow business Cell Adhesion Molecules |
| Zdroj: | Leukemia Research. 16:469-474 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/0145-2126(92)90172-4 |
| Popis: | Acute myeloid leukaemia (AML) cells have a variable capacity to egress from bone marrow into peripheral blood. This may be due to a variable lack of adhesion molecules on leukaemic cells. The expression of VLA1, 3, 4, 5, 6, beta 1-chain, LFA1, beta 2-chain, ICAM1 and NCAM appeared to be higher in bone marrow as compared to peripheral blood leukaemic cells, although this only reached significance for beta 1-chain (p less than 0.01). The number of cases with more than 20% positive cells in bone marrow leukaemic cells was lower in immature FAB-subtypes (M1, M5a) as opposed to more mature subtypes (M2, M3, M4, M5b) for the adhesion molecules tested. This reached significance for VLA5 (p less than 0.05) and beta 1-chain (p less than 0.007), while there was trend for VLA4. It is discussed that VLA4 and 5 may play a role in the release of leukaemic cells from the bone marrow. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|