Design of antihistaminic transdermal films based on alginate–chitosan polyelectrolyte complexes: characterization and permeation studies

Autor:	Nadji Moulai-Mostefa, Sarah N. Gasmi, Sonia Lefnaoui, Madiha M. Yahoum
Rok vydání:	2017
Předmět:	Alginates Polymers Chemistry Pharmaceutical Skin Absorption Histamine Antagonists Transdermal Patch Pharmaceutical Science Alginate chitosan 02 engineering and technology Administration Cutaneous 030226 pharmacology & pharmacy Permeability Chitosan 03 medical and health sciences chemistry.chemical_compound Drug Delivery Systems 0302 clinical medicine Glucuronic Acid Drug Discovery Animals Antiasthmatic drugs Rats Wistar Skin Transdermal Sodium alginate Pharmacology Chromatography Hexuronic Acids Organic Chemistry Permeation 021001 nanoscience & nanotechnology Polyelectrolytes Propylene Glycol Polyelectrolyte Rats Drug Liberation chemistry Delayed-Action Preparations Ketotifen Fumarate 0210 nano-technology
Zdroj:	Drug Development and Industrial Pharmacy. 44:432-443
ISSN:	1520-5762 0363-9045
Popis:	The purpose of this study was to develop suitable matrix-type transdermal drug delivery systems of Ketotifen fumarate (KF) as antiasthmatic drugs. Chitosan-alginate polyelectrolyte complex (PEC) films were used as drug release regulators for KF. Antihistaminic films with variable PEC compositions were prepared using different ratios of chitosan (CTS) to sodium alginate (ALG). Propylene glycol (PG) was used as plasticizer; Tween 80 (T
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7172496f641e34afbc0979f3ee3ad6d3 https://doi.org/10.1080/03639045.2017.1395461 Zobrazit plný text záznamu