Clinical and genetic characteristics of familial hypercholesterolemia patients with type 2 diabetes
Autor: | Yanqiong Zhang, Ye-Xuan Cao, X.-D. You, Gao-Pu Liu, Qiu-Ting Dong, Yushun Gao, Na-Qiong Wu, Cheng-Gen Zhu, Bing-Yang Zhou, Di Sun, Y Guo, Jian Li, Qian Dong, Sha Li |
---|---|
Rok vydání: | 2018 |
Předmět: |
Blood Glucose
Male medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Population 030209 endocrinology & metabolism Coronary Artery Disease Familial hypercholesterolemia Type 2 diabetes Hyperlipoproteinemia Type II Coronary artery disease 03 medical and health sciences 0302 clinical medicine Endocrinology Risk Factors Internal medicine Diabetes mellitus Humans Medicine Risk factor education Triglycerides Glycated Hemoglobin education.field_of_study business.industry nutritional and metabolic diseases Type 2 Diabetes Mellitus Middle Aged Prognosis medicine.disease Lipids Diabetes Mellitus Type 2 030220 oncology & carcinogenesis Female business Body mass index Biomarkers Follow-Up Studies |
Zdroj: | Journal of Endocrinological Investigation. 42:591-598 |
ISSN: | 1720-8386 |
Popis: | Though type 2 diabetes mellitus (T2DM) is an important and independent risk factor for coronary artery disease (CAD) in the general population, the impact of T2DM on CAD in patients with familial hypercholesterolemia (FH) is less understood. Thus, the current study aimed to examine the features of FH patients with T2DM and explore the effects of T2DM on CAD in FH. A total of 289 clinical heterozygous FH (HeFH) patients diagnosed with Dutch Lipid Clinic Criteria were consecutively recruited and divided into a T2DM group (n = 58) and non-T2DM group (n = 231). Clinical characteristics and laboratory findings were compared between the two groups. Target exome sequencing was used for gene mutation analysis. HeFH patients with T2DM had significantly higher levels of triglycerides, body mass index and free fatty acids than did non-T2DM patients; moreover, patients with T2DM more frequently exhibited hypertension. However, the spectrum of FH-causing mutations was not significantly different (p = 0.061). Notably, patients with T2DM had higher prevalence of CAD (p = 0.012) and higher Gensini Score (p = 0.002). The regression analysis confirmed that HbA1c was an independent risk factor for both the presence and severity of CAD [OR 2.321 (1.098–4.904), p = 0.027; OR 1.349 (1.032–1.762), p = 0.028, respectively] in patients with HeFH. Although there were not many differences in the clinical, lipid and genetic aspects of HeFH patients with and without T2DM, T2DM and HbA1c were associated with worse coronary lesions, suggesting that diabetes and the degree of blood glucose control are also important determinants of cardiovascular disease in these patients. |
Databáze: | OpenAIRE |
Externí odkaz: |