Screening of Anticancer and Immunomodulatory Activities of Panamanian Plants
| Autor: | Mireya Correa, Silvia E. Hajos, Mahabir P. Gupta, Teresa Fernández, Pablo N. Solis, Elida Alvarez, Angela I. Calderón, Icela Barberena, Ester Risco, Salvador Cañigueral |
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| Rok vydání: | 2004 |
| Předmět: |
Physiology
Pharmaceutical Science Spleen Pharmacognosy chemistry.chemical_compound Physiology (medical) Drug Discovery medicine Medicinal plants Dichloromethane Pharmacology biology Traditional medicine Cell growth General Medicine biology.organism_classification In vitro Complement system medicine.anatomical_structure Complementary and alternative medicine chemistry Morinda visual_art visual_art.visual_art_medium Molecular Medicine Bark Artemia salina |
| Zdroj: | Archives Of Physiology And Biochemistry. 42:552-558 |
| ISSN: | 1744-4160 1381-3455 |
| DOI: | 10.1080/13880200490901230 |
| Popis: | Fifty-one extracts, from six Panamanian plants species selected on the basis of their toxicities against Artemia salina, belonging to five families and five genera, were screened for their in vitro anticancer (TK-10, UACC-62, MCF-7) and immunomodulatory activities [inhibition of complement, classical (CP) and alternative (AP) complement pathway and lymphoproliferation]. The results showed that 9 (17.6%) of 51 extracts presented anticancer activity against cancer cell lines, while 28 (54.9%) of 51 extracts stimulated normal spleen cells proliferation, and 25 (49.0%) inhibited in vitro lymphoid tumor cell growth. Finally, 7 (19.4%) and 10 (27.8%) out of 36 extracts showed high and moderate anticomplementary activity on CP, respectively. Moreover, out of 36 extracts, 1 (2.8%) produced higher inhibition while 4 (11.1%) showed moderate inhibition in the alternate pathway. The dichloromethane, methanolic and aqueous extracts from the leaf (3.0, 3.2, 4.2) and branch (3.5, 5.7, 5.8) of Trichospermum galeottii and from the leaf (2.4, 2.5, 5.6) and stem (2.3, 2.3, 4.7) of Sauraria yasicae were the most active immunomodulatory plants. The dichloromethane extract from the root of Morinda panamensis (8.7, 4.4, 6.3) was active against the three cancer cell lines, while the dichloromethane extract from the bark of Trichospermum galeottii (TK-10 ¼ 3.4,UACC-62 ¼ 9.4) and the bark of Morinda panamensis (UACC-62 ¼ 5.5, MCF-7 ¼ 5.9) as well as the methanolic extract from the root of Morinda rojoc (UACC-62 ¼ 9.2, MCF-7 ¼ 9.4) exhibited selectivity against two cancer cell lines. |
| Databáze: | OpenAIRE |
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