DYNAMICS OF CD4 CELL COUNT AMONG HIV INFECTED INDIVIDUALS IN LAGOS, NIGERIA
| Autor: | Babatunde Olanrewaju Motayo, Adedayo Omotayo Faneye, Solomon Aturaka, Babatunde A. Olusola, Joseph I Ogiogwa, Olukunle Oluwapamilerin Oluwasemowo |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult CD4-Positive T-Lymphocytes Male medicine.medical_specialty Adolescent Clinical Biochemistry Immunology Population Human immunodeficiency virus (HIV) Early detection Nigeria HIV Infections medicine.disease_cause Cohort Studies 03 medical and health sciences Young Adult 0302 clinical medicine Internal medicine Hiv infected Antiretroviral Therapy Highly Active medicine Antiretroviral treatment Immunology and Allergy Humans Cd4 cell count education Child Survival analysis Aged education.field_of_study business.industry Infant Middle Aged Antiretroviral therapy CD4 Lymphocyte Count Medical Laboratory Technology 030104 developmental biology Child Preschool Female business 030215 immunology |
| DOI: | 10.6084/m9.figshare.5198536.v1 |
| Popis: | Human immunodeficiency virus (HIV) infection leads to progressive loss of CD4 T cells. Antiretroviral therapy has been able to inhibit this process, resulting in significant level of immune recovery and function. Our aim is to investigate the dynamics of CD4 recovery among HIV patients in Lagos, Nigeria. A total of 213 HIV-positive individuals were enrolled between October 2007 and May 2008, and followed up for 9 months based on CD4 count. CD4 analysis was done by flow cytometry at enrollment and after every 3 months. Data were grouped according to age range, antiretroviral treatment (ART), and time between infection and diagnosis. Kaplan-Meier survival analysis was used for data analysis. There was a significant difference in CD4 count between antiretroviral (ART) naive and ART experienced subjects (P < 0.001). About 50% of the ART experienced population was identified to show poor CD4 reconstitution unable to achieve a CD4 of 500 cells/µl after 9 months of therapy. Time interval between infection and therapy was also identified to contribute to poor CD4 restoration. Further studies need to be done to classify immunological nonresponders among HIV patients in Nigeria. We also recommend introduction of programs that will facilitate early detection of HIV infection. |
| Databáze: | OpenAIRE |
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