| Autor: |
S, Kiyama, N, Fujii, H, Yajima, M, Moriga, A, Takagi |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
International Journal of Peptide and Protein Research. 23:174-186 |
| ISSN: |
0367-8377 |
| DOI: |
10.1111/j.1399-3011.1984.tb02708.x |
| Popis: |
The heptacosapeptide amide corresponding to the entire amino acid sequence of chicken secretin was synthesized by assembling four peptide fragments followed by deprotection with thioanisole-mediated trifluoromethanesulfonic acid in TFA. The deprotected peptide was purified by gel-filtration on Sephadex G-25, followed by ion-exchange chromatographies on CM-cellulose and DEAE-Sepharose. Synthetic peptide stimulated the flow of pancreatic alkaline juice and decreased systemic blood pressure in rats. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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