Genetic association analyses of fast plasma glucose level in pre-menopausal Chinese women: potential interaction between osteocalcin and oestrogen receptor α
| Autor: | Lin Zou, Lan Tang, Fuqing Jiang, Chengxin Gong, Yunming Tu, Hong Xu, Luling He, Li-Ping Tan, Dan Luo, Yuping Yang, Lu-Lu Peng, Chaopeng Xiong, Changle Liu, Ya-Jun Cheng, Wei Peng, Shangdong Liang |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Blood Glucose Aging medicine.medical_specialty China endocrine system diseases Physiology Epidemiology Osteocalcin Blood sugar HindIII Polymerase Chain Reaction Young Adult Asian People Internal medicine Genotype Genetics medicine Humans Genetic Association Studies Genetic association biology Public Health Environmental and Occupational Health Estrogen Receptor alpha nutritional and metabolic diseases medicine.disease Menopause Endocrinology Premenopause biology.protein Female Restriction fragment length polymorphism Estrogen receptor alpha Polymorphism Restriction Fragment Length |
| Zdroj: | Annals of human biology. 42(5) |
| ISSN: | 1464-5033 |
| Popis: | Fasting plasma glucose (FPG) levels are usually tightly regulated within a narrow physiologic range. Variation of FPG levels is clinically important and is strongly heritable. Several lines of evidence suggest the importance of the oestrogen receptor α (ER-α) and osteocalcin (also known as BGP, for bone Gla protein) in determining FPG; however, whether their polymorphisms are associated with FPG variation is not well understood.To investigate whether ER-a PvuII and BGP HindIII genetic polymorphisms and their potential interaction are associated with FPG variation.The study subjects were 328 unrelated pre-menopausal Chinese women aged 21 years and over (mean age ± SD, 33.2 ± 5.9 years), with an average FPG of 4.92 (SD = 0.81). All subjects were genotyped at the ER-α PvuII and BGP HindIII loci using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP).The ER-α PvuII genotypes were significantly associated with FPG (p = 0.007). In addition, a significant interaction was observed of the ER-α PvuII polymorphism with BGP HindIII polymorphism on FPG variation (p = 0.013), although the BGP HindIII polymorphism was not shown to be individually associated with FPG.The PvuII polymorphism of the ER-α gene and its potential interaction with the HindIII polymorphism of the BGP gene were associated with FPG in pre-menopausal Chinese women. |
| Databáze: | OpenAIRE |
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