Axial accuracy and signal enhancement in acoustic-resolution photoacoustic microscopy by laser jitter effect correction and pulse energy compensation
| Autor: | Hamid Latifi, Abolfazl Abedi, Manojit Pramanik, Hamed Nikbakht, Hamed Qazvini, Amir Asadollahi, Ali Rezaei |
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| Přispěvatelé: | School of Chemical and Biomedical Engineering, Biophotonics and Medical Imaging, LaserLaB - Biophotonics and Microscopy, Physics of Fluids, MESA+ Institute |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Bioengineering [Engineering]
Materials science Photodetector 01 natural sciences Non-invasive Imaging Article law.invention 010309 optics 03 medical and health sciences Optics Data acquisition law 0103 physical sciences Medical imaging SDG 7 - Affordable and Clean Energy 030304 developmental biology Jitter 0303 health sciences Pulse (signal processing) business.industry Laser High Speed Data Acquisition System Atomic and Molecular Physics and Optics business Energy (signal processing) Biotechnology Degradation (telecommunications) |
| Zdroj: | Biomedical Optics Express, 12(4), 1834-1845. The Optical Society Asadollahi, A, Latifi, H, Pramanik, M, Qazvini, H, Rezaei, A, Nikbakht, H & Abedi, A 2021, ' Axial accuracy and signal enhancement in acoustic-resolution photoacoustic microscopy by laser jitter effect correction and pulse energy compensation ', Biomedical Optics Express, vol. 12, no. 4, pp. 1834-1845 . https://doi.org/10.1364/BOE.419564 Biomedical optics express, 12(4), 1834-1845. The Optical Society Biomed Opt Express |
| ISSN: | 2156-7085 |
| DOI: | 10.1364/BOE.419564 |
| Popis: | © 2021 Optical Society of AmericaIn recent years, photoacoustic imaging has found vast applications in biomedical imaging. Photoacoustic imaging has high optical contrast and high ultrasound resolution allowing deep tissue non-invasive imaging beyond the optical diffusion limit. Q-switched lasers are extensively used in photoacoustic imaging due to the availability of high energy and short laser pulses, which are essential for high-resolution photoacoustic imaging. In most cases, this type of light source suffers from pulse peak-power energy variations and timing jitter noise, resulting in uncertainty in the output power and arrival time of the laser pulses. These problems cause intensity degradation and temporal displacement of generated photoacoustic signals which in turn deteriorate the quality of the acquired photoacoustic images. In this study, we used a high-speed data acquisition system in combination with a fast photodetector and a software-based approach to capture laser pulses precisely in order to reduce the effect of timing jitter and normalization of the photoacoustic signals based on pulse peak-powers simultaneously. In the experiments, maximum axial accuracy enhancement of 14 µm was achieved in maximum-amplitude projected images on XZ and YZ planes with ±13.5 ns laser timing jitter. Furthermore, photoacoustic signal enhancement of 77% was obtained for 75% laser pulses peak-power stability. |
| Databáze: | OpenAIRE |
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