Brain Training Games Enhance Cognitive Function in Healthy Subjects
| Autor: | Muhammad Iqbal, Abdulrahman Al-Thaqib, Fahad Al-Sultan, Fahad Al-Kahtani, Shahid Bashir, Abdullah Alzahrani, Khalid A. Al-Regaiey |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Memory Long-Term Motor Activity Neuropsychological Tests Audiology Statistics Nonparametric 050105 experimental psychology law.invention 03 medical and health sciences Cognition 0302 clinical medicine Visual memory Randomized controlled trial Memory law Task Performance and Analysis Reaction Time medicine Humans Memory functions Attention 0501 psychology and cognitive sciences Latency (engineering) Demography business.industry 05 social sciences Brain General Medicine Executive functions Healthy Volunteers Cognitive training Human Study Games Experimental Pattern Recognition Physiological Female Observational study business 030217 neurology & neurosurgery |
| Zdroj: | Medical Science Monitor Basic Research |
| ISSN: | 2325-4416 |
| DOI: | 10.12659/msmbr.909022 |
| Popis: | BACKGROUND Brain training games (BTG) are believed to play a major role in improving cognitive functions. The current study evaluated if BTG showed positive impact on attention and memory functions compared with baseline visit in healthy subjects. MATERIAL AND METHODS The study was carried out from October 2015 until April 2016 in the Department of Physiology, College of Medicine, King Saud University and in King Khalid University Hospital (KKUH), Riyadh, Saudi Arabia. We enrolled 51 normal healthy subjects to use a computerized cognitive training game (Lumosity) for exercises that target a range of cognitive functions, including attention, processing speed, visual memory, and executive functions for about 15 min per day, at least 7 days per week, for 3 weeks. The control (n=21) group did not perform the training. Both groups took the CANTAB test before and 3 weeks after training for various cognitive functions (flexibility, memory, attention, speed, and problem solving). Serum samples were used to study the brain-derived growth factor (BDNF) and apolipoprotein (Apo) E (APOE) levels. RESULTS A significant improvement in Lumosity performance index was observed in the active group compared to the control group by the end of training (p-value 0.001). After the training, a statistically significant difference in most of the CANTAB measures, such as attention-switching task (AST), mean correct latency, AST switching cost, AST mean correct latency (congruent), AST mean correct latency (incongruent), AST mean correct latency (blocks 3 and 5) [non-switching blocks], AST mean correct latency (block 7) [switching block], and MOT mean correct latency (all P=0.000). However, in the control group, significant improvements were not observed. A positive correlation between pattern recognition memory (PRM) and APOE was found and people who had higher ApoE levels had faster response. CONCLUSIONS An improvement in different cognitive domains was noted, including attention and motor speed. However, this study warrants further research to determine the long-term effect on other cognitive functions and in different groups (e.g., elderly vs. adults). |
| Databáze: | OpenAIRE |
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