Plitidepsin as a successful rescue treatment for prolonged viral SARS-CoV-2 replication in a patient with previous anti-CD20 monoclonal antibody-mediated B cell depletion and chronic lymphocytic leukemia
| Autor: | Guisado-Vasco, P., Carralón-González, M. M., Aguareles-Gorines, J., Martí-Ballesteros, E. M., Sánchez-Manzano, M. D., Carnevali-Ruiz, D., García-Coca, M., Barrena-Puertas, R., de Viedma, R. García, Luque-Pinilla, J. M., Sotres-Fernandez, G., Fernández-Sousa, J. M., Luepke-Estefan, X. E., López-Martín, J. A., Jimeno, J. M. |
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| Rok vydání: | 2022 |
| Předmět: |
Cancer Research
SARS-CoV-2 Anti-CD20 monoclonal antibody Neoplasms. Tumors. Oncology. Including cancer and carcinogens Hematology Oncology Prolonged viral replication Plitidepsin Chronic lymphocytic leukemia Diseases of the blood and blood-forming organs RC633-647.5 Covid-19 Letter to the Editor Molecular Biology RC254-282 |
| Zdroj: | Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-4 (2022) Journal of Hematology & Oncology |
| ISSN: | 1756-8722 |
| Popis: | BackgroundThere is an urgent need for highly efficacious antiviral therapies in immunosuppressed hosts who develop coronavirus disease (COVID-19), with special concern for those affected by hematological malignancies.Case presentationHere, we report the case of a 75-year-old male with chronic lymphocytic leukemia who was deficient in CD19+CD20+B-lymphocyte populations due to previous treatment with anti-CD20 monoclonal antibodies. The patient presented with severe COVID-19 pneumonia due to prolonged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and was treated with two courses of the antiviral plitidepsin on a compassionate use basis. The patient subsequently achieved an undetectable viral load, and his pneumonia resolved.ConclusionsTreatment with plitidepsin was well-tolerated without any further hematological or cardiovascular toxicities. This case further supports plitidepsin as a potential antiviral drug in SARS-CoV-2 patients affected by immune deficiencies and hematological malignancies. |
| Databáze: | OpenAIRE |
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