Exhaled breath condensate biomarkers in critically ill, mechanically ventilated patients
| Autor: | Brett R Winters, Curtis N. Sessler, Cavin K. Ward-Caviness, M. Ariel Geer Wallace, Joachim D. Pleil, Michael C. Madden, Alison J. Montpetit, Michael D. Davis |
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| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty Critical Illness Interleukin-1beta 01 natural sciences Article Sepsis 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Humans Exhaled breath condensate medicine.diagnostic_test business.industry Critically ill Tumor Necrosis Factor-alpha 010401 analytical chemistry Exhalation Odds ratio Pneumonia Middle Aged Thorax medicine.disease Respiration Artificial Confidence interval 0104 chemical sciences respiratory tract diseases Treatment Outcome 030228 respiratory system Breath Tests Acute Disease Linear Models business Chest radiograph Biomarkers |
| Zdroj: | J Breath Res |
| ISSN: | 1752-7163 |
| Popis: | Pneumonia is a significant risk for critically ill, mechanically ventilated (CIMV) patients. Diagnosis of pneumonia generally requires a combination of clinician-guided diagnoses and clinical scoring systems. Exhaled breath condensate (EBC) can be safely collected non-invasively from CIMV patients. Hundreds of biomarkers in EBC are associated with acute disease states, including pneumonia. We evaluated cytokines in EBC from CIMV patients and hypothesized that these biomarkers would correlate with disease severity in pneumonia, sepsis, and death. EBC IL-2 levels were associated with chest radiograph severity scores (odds ratio = 1.68; 95% confidence interval = 1.09–2.60; P = 0.02). EBC TNF-α levels were also associated with pneumonia (odds ratio = 3.20; 95% confidence interval = 1.19–8.65; P = 0.02). The techniques and results from this study may be useful for all mechanically ventilated patients. |
| Databáze: | OpenAIRE |
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