Spatiotemporal regulation of type I interferon expression determines the antiviral polarization of CD4+ T cells
| Autor: | Claudia Cristofani, Mirela Kuka, Chiara Medaglia, Sarah Eickhoff, Valeria Cutillo, Wolfgang Kastenmüller, Ido Amit, Amir Giladi, Marco De Giovanni, Eleonora Consolo, Eleonora Sala, Matteo Iannacone, Alessandra Fiore, Pietro Di Lucia, Elisa Bono, Leonardo Giustini, Carmela G. Maganuco |
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| Přispěvatelé: | De Giovanni, M., Cutillo, V., Giladi, A., Sala, E., Maganuco, C. G., Medaglia, C., Di Lucia, P., Bono, E., Cristofani, C., Consolo, E., Giustini, L., Fiore, A., Eickhoff, S., Kastenmuller, W., Amit, I., Kuka, M., Iannacone, M. |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male medicine.medical_treatment T cell Immunology Mice Transgenic Biology Adaptive Immunity Lymphocytic choriomeningitis Epitope 03 medical and health sciences Mice 0302 clinical medicine Interferon medicine Immunology and Allergy Vesicular stomatitis Indiana viru Animal Interleukin-6 Lymphocyte differentiation Cell Differentiation T-Lymphocytes Helper-Inducer Acquired immune system medicine.disease Adoptive Transfer Lymphocytic choriomeningitis viru 3. Good health Cell biology Mice Inbred C57BL 030104 developmental biology Cytokine medicine.anatomical_structure Th1 Cell CD4-Positive T-Lymphocyte T cell differentiation Interferon Type I Vesicular stomatitis New Jersey virus Female Spatio-Temporal Analysi 030215 immunology medicine.drug |
| Zdroj: | Nature Immunology |
| Popis: | Differentiation of CD4+ T cells into either follicular helper T (TFH) or type 1 helper T (TH1) cells influences the balance between humoral and cellular adaptive immunity, but the mechanisms whereby pathogens elicit distinct effector cells are incompletely understood. Here we analyzed the spatiotemporal dynamics of CD4+ T cells during infection with recombinant vesicular stomatitis virus (VSV), which induces early, potent neutralizing antibodies, or recombinant lymphocytic choriomeningitis virus (LCMV), which induces a vigorous cellular response but inefficient neutralizing antibodies, expressing the same T cell epitope. Early exposure of dendritic cells to type I interferon (IFN), which occurred during infection with VSV, induced production of the cytokine IL-6 and drove TFH cell polarization, whereas late exposure to type I IFN, which occurred during infection with LCMV, did not induce IL-6 and allowed differentiation into TH1 cells. Thus, tight spatiotemporal regulation of type I IFN shapes antiviral CD4+ T cell differentiation and might instruct vaccine design strategies. Iannacone and colleagues show that the spatiotemporal regulation of type I interferon expression shapes the differentiation of antiviral CD4+ T cells into TFH or TH1 cells. |
| Databáze: | OpenAIRE |
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