Trends of skin cancer mortality after transplantation in the United States: 1987 to 2013
| Autor: | Jonathan P. Singer, Giorgia L. Garrett, Stefan E. Lowenstein, Sarah T. Arron, Steven Y. He |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Skin Neoplasms Adolescent Population Dermatology Organ transplantation Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences Sex Factors 0302 clinical medicine Risk Factors Internal medicine medicine Humans Mortality education Melanoma Aged Cause of death education.field_of_study business.industry Merkel cell carcinoma Hazard ratio Organ Transplantation Middle Aged medicine.disease United States Surgery Carcinoma Merkel Cell Transplantation Standardized mortality ratio 030220 oncology & carcinogenesis Carcinoma Squamous Cell Female Skin cancer business |
| Zdroj: | Journal of the American Academy of Dermatology. 75:106-112 |
| ISSN: | 0190-9622 |
| DOI: | 10.1016/j.jaad.2016.02.1155 |
| Popis: | Background Solid organ transplant recipients are at increased risk of skin cancer, but population-based mortality data are limited. Objective Mortality and predictors of skin cancer death posttransplantation were investigated. Methods All US organ transplant recipients between 1987 and 2013, identified through the Organ Procurement and Transplantation Network Standard Transplant Analysis and Research file, were included. Mortality and hazard ratios (HR) were calculated for the overall population and patient subgroups. Results The overall mortality was 5308 per 100,000 person-years and the skin cancer–specific mortality was 35.27 per 100,000 person-years. Risk factors associated with skin cancer death included thoracic versus abdominal transplantation (HR 2.90, 95% confidence interval [CI] 2.52-3.34), age over 50 years (HR 2.86, CI 2.43-3.38), white race (HR 6.29, CI 4.63-8.53), and male sex (HR 1.85, CI 1.57-2.19). Mortality was highest for malignant melanoma (mortality of 11.48), followed by squamous cell carcinoma (mortality of 4.94) and Merkel cell carcinoma (mortality of 4.59). Limitations Limitations of this study included potential underreporting and misclassification of death from skin cancer in the data set. Conclusion Mortality from posttransplantation skin cancer is reported. Older patients, male patients, white patients, and thoracic transplant recipients had increased mortality from skin cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect