Definition and review on a category of long non-coding RNA: Atherosclerosis-associated circulating lncRNA (ASCLncRNA)
| Autor: | Yanqing Huang, Qin Liang, Shanshan Lu, Fanming Meng, Junwen Liu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cardiology
lcsh:Medicine Biology Bioinformatics General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Non-invasive diagnosis Pathology Pathological Molecular Biology 030304 developmental biology 0303 health sciences MALAT1 KCNQ1OT1 General Neuroscience lcsh:R Diagnostic marker General Medicine Biomarker Atherosclerosis Long non-coding RNA Microvesicles Biomarker (cell) 030220 oncology & carcinogenesis Potential biomarkers Circulating lncRNAs General Agricultural and Biological Sciences |
| Zdroj: | PeerJ PeerJ, Vol 8, p e10001 (2020) |
| ISSN: | 2167-8359 |
| Popis: | Atherosclerosis (AS) is one of the most common cardiovascular system diseases which seriously affects public health in modern society. Finding potential biomarkers in the complicated pathological progression of AS is of great significance for the prevention and treatment of AS. Studies have shown that long noncoding RNAs (lncRNAs) can be widely involved in the regulation of many physiological processes, and have important roles in different stages of AS formation. LncRNAs can be secreted into the circulatory system through exosomes, microvesicles, and apoptotic bodies. Recently, increasing studies have been focused on the relationships between circulating lncRNAs and AS development. The lncRNAs in circulating blood are expected to be new non-invasive diagnostic markers for monitoring the progression of AS. We briefly reviewed the previously reported lncRNA transcripts which related to AS development and detectable in circulating blood, including ANRIL, SENCR, CoroMarker, LIPCAR, HIF1α-AS1, LncRNA H19, APPAT, KCNQ1OT1, LncPPARδ, LincRNA-p21, MALAT1, MIAT, and UCA1. Further researches and a definition of atherosclerosis-associated circulating lncRNA (ASCLncRNA) were also discussed. |
| Databáze: | OpenAIRE |
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