Step of Dichlorvos Inhibition in the Pathway of Aflatoxin Biosynthesis
| Autor: | Raymond C. Yao, Dennis P. H. Hsieh |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Aflatoxin
Chemical Phenomena Orange (colour) Acetates General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Pigment Aflatoxins Biosynthesis Dichlorvos heterocyclic compounds Carbon Radioisotopes General Pharmacology Toxicology and Pharmaceutics Metabolism and Products Aspergillus Chromatography General Immunology and Microbiology biology fungi technology industry and agriculture food and beverages Pigments Biological General Medicine biology.organism_classification biological factors Aspergillus parasiticus Chemistry chemistry Biochemistry visual_art visual_art.visual_art_medium Autoradiography Chromatography Thin Layer Sterigmatocystin |
| Zdroj: | Applied Microbiology. 28:52-57 |
| ISSN: | 0003-6919 |
| DOI: | 10.1128/am.28.1.52-57.1974 |
| Popis: | Dichlorvos (dimethyl 2,2-dichlorovinyl phosphate) inhibits the biosynthesis of aflatoxin by Aspergillus parasiticus . Cultures treated with dichlorvos excrete an orange pigment which can be converted into aflatoxin B 1 by the untreated mycelia. The orange pigment was partially identified as an acetyl derivative of versiconol-type compound. In the presence of dichlorvos, sterigmatocystin is converted into aflatoxin B 1 without being interfered, but averufin is converted into the orange pigment instead of aflatoxin B 1 . Therefore, dichlorvos appears to block an enzymatic step in the aflatoxin biosynthetic pathway, which lies beyond averufin but before sterigmatocystin, at the formation of the orange pigment. |
| Databáze: | OpenAIRE |
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