The Independent Contribution of Uterine Blood Flow to Birth Weight and Body Composition in Smoking Mothers
| Autor: | Ira M. Bernstein, Sarah H. Heil, Kylie M. Cooper, Joan M. Skelly, Stephen T. Higgins |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Birth weight Mothers Hemodynamics Gestational Age Ultrasonography Prenatal Body Mass Index Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy Internal medicine medicine.artery medicine Birth Weight Humans Prospective Studies 030212 general & internal medicine Uterine artery Ultrasonography Doppler Duplex Fetus 030219 obstetrics & reproductive medicine Obstetrics business.industry Smoking Uterus Infant Newborn Pregnancy Outcome Obstetrics and Gynecology Gestational age Stepwise regression Confidence interval Uterine Artery Endocrinology Regional Blood Flow Pediatrics Perinatology and Child Health Body Composition Lean body mass Regression Analysis Female business |
| Zdroj: | American Journal of Perinatology. 35:521-526 |
| ISSN: | 1098-8785 0735-1631 |
| Popis: | Objective This study aims to evaluate the relationship of maternal smoking to uterine artery hemodynamics and examine independent contributions to birth weight and fetal body composition. Study Design Women were enrolled in a prospective randomized controlled study targeting smoking abstinence. Uterine artery Doppler ultrasound was performed and volumetric blood flow was calculated. Third trimester ultrasound estimates of fetal body composition were performed and birth weight was recorded. Results Uterine artery volumetric flow and resistance index (RI) were significantly correlated with birth weight adjusted for gestational age (R = 0.35, p = 0.002; R = − 0.27, p = 0.02). Volumetric flow was significantly associated with fetal fat mass (R = 0.30, p = 0.018). Smoking status did not have significant effects on lean body mass (t [61] = 0.60, p = 0.55), fat mass (t [61] = 1.67, p = 0.10), or volumetric flow (t = 0.86, df = 87, p = 0.39). Stepwise regression identified volumetric flow (β = 0.81, 95% confidence interval [CI]: 0.35–1.27, p Conclusion No direct relationship of smoking to uterine artery hemodynamics was demonstrated. Volumetric flow was an independent contributor to birth weight and was associated with fetal fat deposition, while smoking was not independently associated with either outcome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|