Raf1, Aurora-A/STK15 and E-cadherin biomarkers expression in patients with pTa/pT1 urothelial bladder carcinoma; a retrospective TMA study of 246 patients with long-term follow-up

Autor: Richard T. Cheney, Paulette Mhawech-Fauceglia, François Herrmann, Amy Beck, Gabor Fischer
Jazyk: angličtina
Rok vydání: 2006
Předmět:
Oncology
Male
Pathology
Carcinoma/*metabolism/pathology
Aurora Kinases
Stage (cooking)
Aurora Kinase A
Bladder Neoplasms/*metabolism/pathology
Aged
80 and over
Tissue microarray
biology
Protein-Serine-Threonine Kinases/*biosynthesis
General Medicine
Middle Aged
Cadherins
Prognosis
Immunohistochemistry
Proto-Oncogene Proteins c-raf/*biosynthesis
Urothelium/pathology
Female
Antibody
Adult
medicine.medical_specialty
Protein Serine-Threonine Kinases
Tumor Markers
Biological/*biosynthesis
Text mining
Internal medicine
Biomarkers
Tumor
medicine
Carcinoma
Humans
In patient
Comparative Study
Neoplasm Invasiveness
Aged
Retrospective Studies
Proportional hazards model
Cadherin
business.industry
Cadherins/*biosynthesis
medicine.disease
Proto-Oncogene Proteins c-raf
Urinary Bladder Neoplasms
Tissue Array Analysis
ddc:618.97
biology.protein
Surgery
Urothelium
business
Follow-Up Studies
Zdroj: European Journal of Surgical Oncology, Vol. 32, No 4 (2006) pp. 439-444
ISSN: 0748-7983
Popis: AIMS: The study was designed to evaluate Raf1, Aurora-A/STK15 and E-cadherin (E-CD) protein expression and their prognostic value in patients with pTa/pT1 tumours. MATERIALS AND METHODS: A tissue microarray of 105 pTa, and 141 pT1 tumours was constructed and sections were immunostained with these three antibodies. RESULTS: There were significant associations between Raf1 overexpression and tumour grade (p = 0.03), between Aurora-A overexpression/alterations of E-CD and tumour grade and stage (p < 0.001 and p < 0.001). In multiple Cox regression analysis, moderate/strong expression of E-CD seemed to be an independent factor in predicting slower tumour progression (p = 0.003) and Aurora-A overexpression (p = 0.022) displays an independent value in predicting tumour recurrences. CONCLUSION: Evaluation of E-CD and Aurora-A expressions in tissue of patients with pTa/pT1 UC have been proven to be useful in predicting tumours behavior and Raf1 protein expression seemed to have no potential use in this regard.
Databáze: OpenAIRE
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