Raf1, Aurora-A/STK15 and E-cadherin biomarkers expression in patients with pTa/pT1 urothelial bladder carcinoma; a retrospective TMA study of 246 patients with long-term follow-up
Autor: | Richard T. Cheney, Paulette Mhawech-Fauceglia, François Herrmann, Amy Beck, Gabor Fischer |
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Jazyk: | angličtina |
Rok vydání: | 2006 |
Předmět: |
Oncology
Male Pathology Carcinoma/*metabolism/pathology Aurora Kinases Stage (cooking) Aurora Kinase A Bladder Neoplasms/*metabolism/pathology Aged 80 and over Tissue microarray biology Protein-Serine-Threonine Kinases/*biosynthesis General Medicine Middle Aged Cadherins Prognosis Immunohistochemistry Proto-Oncogene Proteins c-raf/*biosynthesis Urothelium/pathology Female Antibody Adult medicine.medical_specialty Protein Serine-Threonine Kinases Tumor Markers Biological/*biosynthesis Text mining Internal medicine Biomarkers Tumor medicine Carcinoma Humans In patient Comparative Study Neoplasm Invasiveness Aged Retrospective Studies Proportional hazards model Cadherin business.industry Cadherins/*biosynthesis medicine.disease Proto-Oncogene Proteins c-raf Urinary Bladder Neoplasms Tissue Array Analysis ddc:618.97 biology.protein Surgery Urothelium business Follow-Up Studies |
Zdroj: | European Journal of Surgical Oncology, Vol. 32, No 4 (2006) pp. 439-444 |
ISSN: | 0748-7983 |
Popis: | AIMS: The study was designed to evaluate Raf1, Aurora-A/STK15 and E-cadherin (E-CD) protein expression and their prognostic value in patients with pTa/pT1 tumours. MATERIALS AND METHODS: A tissue microarray of 105 pTa, and 141 pT1 tumours was constructed and sections were immunostained with these three antibodies. RESULTS: There were significant associations between Raf1 overexpression and tumour grade (p = 0.03), between Aurora-A overexpression/alterations of E-CD and tumour grade and stage (p < 0.001 and p < 0.001). In multiple Cox regression analysis, moderate/strong expression of E-CD seemed to be an independent factor in predicting slower tumour progression (p = 0.003) and Aurora-A overexpression (p = 0.022) displays an independent value in predicting tumour recurrences. CONCLUSION: Evaluation of E-CD and Aurora-A expressions in tissue of patients with pTa/pT1 UC have been proven to be useful in predicting tumours behavior and Raf1 protein expression seemed to have no potential use in this regard. |
Databáze: | OpenAIRE |
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