Circadian heme oxygenase activity in the hamster suprachiasmatic nuclei
| Autor: | Gabriela A. Ferreyra, Patricia V. Agostino, Marı́a Fernanda Rubio, Diego A. Golombek |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Time Factors Blotting Western Hamster Protoporphyrins Endogeny Biology In Vitro Techniques Motor Activity chemistry.chemical_compound Internal medicine Cricetinae medicine Animals Circadian rhythm Enzyme Inhibitors Behavior Animal Suprachiasmatic nucleus General Neuroscience Bilirubin Darkness Circadian Rhythm Heme oxygenase Endocrinology chemistry Liver Hypothalamus Heme Oxygenase (Decyclizing) Suprachiasmatic Nucleus sense organs Signal transduction Photic Stimulation Hemin |
| Zdroj: | Neuroscience letters. 353(1) |
| ISSN: | 0304-3940 |
| Popis: | Entrainment of mammalian circadian rhythms requires the activation of specific signal transduction pathways in the hypothalamic suprachiasmatic nuclei (SCN). We have tested the participation of heme oxygenase (HO) in the SCN, by assessing HO specific activity at different time points and photic conditions. HO activity was determined by the conversion of hemin to bilirubin. HO enzymatic activity in the SCN was significantly higher during the night than during the day; this difference persisted when animals were placed under constant darkness, suggesting an endogenous circadian control. HO inhibition by Zn-protoporphyrin did not affect light-induced phase shifts in vivo, suggesting that the enzyme is not necessary for light input to the clock. |
| Databáze: | OpenAIRE |
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