Signaling pathways involved in thyroid hyperfunction and growth in Graves' disease
| Autor: | Daniela Corda, Alfredo Di Cerbo |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
endocrine system
endocrine system diseases Graves' disease Thyroid Gland Disease Biology Biochemistry Adenylyl cyclase Pathogenesis chemistry.chemical_compound medicine Animals Humans Phospholipase A Phospholipase C Thyroid Receptors Thyrotropin General Medicine medicine.disease Graves Disease medicine.anatomical_structure chemistry Immunoglobulin G Immunology Signal transduction Signal Transduction |
| Zdroj: | Biochimie. 81(5) |
| ISSN: | 0300-9084 |
| Popis: | The elucidation of the multiple signaling cascades coupled to the TSH receptor has offered new approaches in the understanding of the pathogenesis of Graves' disease. Here we review findings showing that immunoglobulins from Graves' patients are heterogeneous, bind to different epitopes and, similarly to TSH, activate different signaling pathways, including adenylyl cyclase, phospholipase C and phospholipase A2. Evidence that the multiplicity of signals correlates with the different manifestations of the disease is also summarized. We believe that the dissection of the molecular mechanisms involved in the pathogenesis of Graves' disease offers the basis for developing novel therapeutical approaches to this disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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