Treatment of advanced colorectal cancer with mitoxantrone, high dose folinic acid and fluorouracil
| Autor: | Parziale Ap, Antonio Daponte, Pasquale Comella, Rossana Casaretti, G. Santillo, Iervolino, Zarrilli D, Giuseppe Comella |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Colorectal cancer Leucovorin Rectum Gastroenterology Drug Administration Schedule 030218 nuclear medicine & medical imaging 03 medical and health sciences Folinic acid 0302 clinical medicine Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Carcinoma Humans Aged Neoplasm Staging Mitoxantrone business.industry Combination chemotherapy General Medicine Middle Aged medicine.disease Regimen medicine.anatomical_structure Oncology Fluorouracil 030220 oncology & carcinogenesis Female business Colorectal Neoplasms medicine.drug |
| Zdroj: | Tumori. 77(5) |
| ISSN: | 0300-8916 |
| Popis: | A new combination chemotherapy including mitoxantrone 10 mg/m2 i.v. on day 1 and 5-fluorouracil 400 mg/m2 i.v. plus folinic acid 200 mg/m2 i.v. on days 1-5 was administered every 28 days to 13 patients with locally advanced or metastatic colon (1 case), rectosigmoid colon (4 cases), or rectum (8 cases) carcinoma. The median number of cycles performed was 3 (range, 1-9). No patient achieved complete or partial remission with this regimen, whereas 5 showed a stable disease lasting 3-8 months. Acute toxicity was mild/moderate in intensity and comparable to that reported with the standard 5-fluorouracil + folinic acid combination. Since we observed no major responses in our 13 consecutive patients, we consider that the overall activity of our regimen, at the doses and schedule utilized, was only moderately effective in advanced colorectal carcinoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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