Case-control study of adverse childhood experiences and multiple sclerosis risk and clinical outcomes

Autor: Mary K. Horton, Shannon McCurdy, Xiaorong Shao, Kalliope Bellesis, Terrence Chinn, Catherine Schaefer, Lisa F. Barcellos
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Male
Epidemiology
Social Sciences
Criminology
Severity of Illness Index
Pediatrics
Medical Conditions
Cognition
Learning and Memory
Sociology
Adverse Childhood Experiences
Divorce
Risk Factors
Odds Ratio
Medicine and Health Sciences
Ethnicities
Public and Occupational Health
Child Abuse
Child
African American people
Multidisciplinary
Cancer Risk Factors
Traumatic Injury Risk Factors
Substance Abuse
Neurodegenerative Diseases
Middle Aged
Population groupings
Neurology
Oncology
Memory Recall
Medicine
Female
Crime
Research Article
Adult
Multiple Sclerosis
Substance-Related Disorders
Science
Immunology
Autoimmune Diseases
Memory
Mental Health and Psychiatry
Humans
Parental Death
Aged
Biology and Life Sciences
Demyelinating Disorders
Logistic Models
Case-Control Studies
Medical Risk Factors
Linear Models
Cognitive Science
Clinical Immunology
Clinical Medicine
People and places
Neuroscience
Zdroj: PLoS ONE, Vol 17, Iss 1, p e0262093 (2022)
PLoS ONE
ISSN: 1932-6203
Popis: Background Adverse childhood experiences (ACEs) are linked to numerous health conditions but understudied in multiple sclerosis (MS). This study’s objective was to test for the association between ACEs and MS risk and several clinical outcomes. Methods We used a sample of adult, non-Hispanic MS cases (n = 1422) and controls (n = 1185) from Northern California. Eighteen ACEs were assessed including parent divorce, parent death, and abuse. Outcomes included MS risk, age of MS onset, Multiple Sclerosis Severity Scale score, and use of a walking aid. Logistic and linear regression estimated odds ratios (ORs) (and beta coefficients) and 95% confidence intervals (CIs) for ACEs operationalized as any/none, counts, individual events, and latent factors/patterns. Results Overall, more MS cases experienced ≥1 ACE compared to controls (54.5% and 53.8%, respectively). After adjusting for sex, birthyear, and race, this small difference was attenuated (OR = 1.01, 95% CI: 0.87, 1.18). There were no trends of increasing or decreasing odds of MS across ACE count categories. Consistent associations between individual ACEs between ages 0–10 and 11–20 years and MS risk were not detected. Factor analysis identified five latent ACE factors, but their associations with MS risk were approximately null. Age of MS onset and other clinical outcomes were not associated with ACEs after multiple testing correction. Conclusion Despite rich data and multiple approaches to operationalizing ACEs, no consistent and statistically significant effects were observed between ACEs with MS. This highlights the challenges of studying sensitive, retrospective events among adults that occurred decades before data collection.
Databáze: OpenAIRE
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