Progesterone oral contraception and blood coagulation
| Autor: | Jean M. Thomson, Anne Tabiowo, Leon Poller, Celia M. Priest |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
medicine.medical_specialty
Chlormadinone Acetate Fibrinogen chemistry.chemical_compound Chlormadinone acetate Internal medicine medicine Humans Blood Coagulation General Environmental Science Blood coagulation test Prothrombin time medicine.diagnostic_test Factor VII business.industry Factor X General Engineering Estrogens General Medicine Thromboelastography Endocrinology chemistry Prothrombin Time General Earth and Planetary Sciences Female Blood Coagulation Tests business Research Article Contraceptives Oral Chlormadinone medicine.drug |
| Zdroj: | BMJ. 1:554-556 |
| ISSN: | 1468-5833 0959-8138 |
| DOI: | 10.1136/bmj.1.5643.554 |
| Popis: | The effects on blood coagulation of oral contraception with continuous progestorone (0.5 mg chlormadinone acetate daily for 3 months) were studied in 76 women 37 (group 1) who had not previously taken any oral contraceptive and 23 (group 2) who had already been taking some combined or sequential preparations. Group 1 women had no significant increase in coagulability and platelet aggregation though an increase in fibrinolytic activity was suggested. Those tested by thromboelastography in this group showed no change in their thromboelastographic pattern. Before chlormadinone therapy group 2 women showed significant shortening of the prothrombin time and raised levels of factors VII and X. By the second month of chlormadinone administration the prothrombin time was normal. After the third month the factor VII level was no longer significantly increased but factor X although falling was still significantly high. Test results are encouraging for use of progesterone alone. Long-term work must be done to substantiate whether the thrombogenic element in the conventional oral contraceptive may have been eliminated by the use of progesterone alone. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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