The Ancient Evolutionary History of Polyomaviruses
| Autor: | James M. Pipas, Jennifer A. Dill, Eric Delwart, Diana V. Pastrana, Joshua P. Katz, Alexa J. McDermott, Koenraad Van Doorslaer, Christopher B. Buck, Arvind Varsani, Terry Fei Fan Ng, Kata Farkas, Alberto Peretti, Ping An, Alvin C. Camus, Charlotte Austin, Alison A. McBride, William Davison, Simona Kraberger, Michael J. Tisza, Eileen M. Geoghegan |
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| Přispěvatelé: | Department of Clinical Laboratory Sciences, Faculty of Health Sciences |
| Rok vydání: | 2016 |
| Předmět: |
Models
Molecular 0301 basic medicine Viral metagenomics viruses Pathology and Laboratory Medicine Database and Informatics Methods Invertebrate Genomics Medicine and Health Sciences Biology (General) Phylogeny Phylogenetic tree Fishes virus diseases Phylogenetic Analysis Genomics DNA Tumor Virus Genomic Databases Biological Evolution Medical Microbiology Viral Pathogens Viruses Fish Pathogens Polyomavirus Sequence Analysis Research Article Family Polyomaviridae QH301-705.5 Molecular Sequence Data Immunology Sequence Databases Biology Research and Analysis Methods Microbiology Viral Evolution Host-Parasite Interactions Scorpions 03 medical and health sciences Sequence Motif Analysis Virology Genetics Animals Amino Acid Sequence Molecular Biology Techniques Sequencing Techniques Microbial Pathogens Molecular Biology Gene DNA sequence analysis Molecular Biology Assays and Analysis Techniques Evolutionary Biology Sheep Biology and life sciences Base Sequence Organisms Computational Biology Biological classification RC581-607 biochemical phenomena metabolism and nutrition Genome Analysis Organismal Evolution Polyomaviruses Biological Databases 030104 developmental biology Animal Genomics Evolutionary biology Microbial Evolution Parasitology Immunologic diseases. Allergy DNA viruses |
| Zdroj: | PLoS Pathogens, Vol 12, Iss 4, p e1005574 (2016) PLoS Pathogens PLoS One |
| ISSN: | 1553-7374 |
| Popis: | Polyomaviruses are a family of DNA tumor viruses that are known to infect mammals and birds. To investigate the deeper evolutionary history of the family, we used a combination of viral metagenomics, bioinformatics, and structural modeling approaches to identify and characterize polyomavirus sequences associated with fish and arthropods. Analyses drawing upon the divergent new sequences indicate that polyomaviruses have been gradually co-evolving with their animal hosts for at least half a billion years. Phylogenetic analyses of individual polyomavirus genes suggest that some modern polyomavirus species arose after ancient recombination events involving distantly related polyomavirus lineages. The improved evolutionary model provides a useful platform for developing a more accurate taxonomic classification system for the viral family Polyomaviridae. Author Summary Polyomaviruses are a family of DNA-based viruses that are known to infect various terrestrial vertebrates, including humans. In this report, we describe our discovery of highly divergent polyomaviruses associated with various marine fish. Searches of public deep sequencing databases unexpectedly revealed the existence of polyomavirus-like sequences in scorpion and spider datasets. Our analysis of these new sequences suggests that polyomaviruses have slowly co-evolved with individual host animal lineages through an established mechanism known as intrahost divergence. The proposed model is similar to the mechanisms through with other DNA viruses, such as papillomaviruses, are thought to have evolved. Our analysis also suggests that distantly related polyomaviruses sometimes recombine to produce new chimeric lineages. We propose a possible taxonomic scheme that can account for these inferred ancient recombination events. |
| Databáze: | OpenAIRE |
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