Differential transcription profiles of long non-coding RNAs in primary human brain microvascular endothelial cells in response to meningitic Escherichia coli
| Autor: | Ling Miao, Xiangru Wang, Huanchun Chen, Bojie Xu, Ruicheng Yang, Wen-Tong Liu, Beibei Dou, Chen Tan, Jiyang Fu, Fei Huang, Xiaopei Yang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Meningitis Escherichia coli Cell Primary Cell Culture Biology Article Proinflammatory cytokine Meningitis Bacterial 03 medical and health sciences Downregulation and upregulation medicine Escherichia coli Humans RNA Messenger Regulation of gene expression Inflammation Multidisciplinary Gene Expression Profiling RNA Endothelial Cells Cell biology Gene expression profiling 030104 developmental biology medicine.anatomical_structure Gene Expression Regulation Cell culture Blood-Brain Barrier Immunology RNA Long Noncoding Inflammation Mediators Astrocyte |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Accumulating studies have indicated the influence of long non-coding RNAs (lncRNAs) on various biological processes as well as disease development and progression. However, the lncRNAs involved in bacterial meningitis and their regulatory effects are largely unknown. By RNA-sequencing, the transcriptional profiles of host lncRNAs in primary human brain microvascular endothelial cells (hBMECs) in response to meningitic Escherichia coli were demonstrated. Here, 25,257 lncRNAs were identified, including 24,645 annotated lncRNAs and 612 newly found ones. A total of 895 lncRNAs exhibited significant differences upon infection, among which 382 were upregulated and 513 were downregulated (≥2-fold, p E. coli-induced meningitis have been reported, which shall provide novel insight into the regulatory mechanisms behind bacterial meningitis involving lncRNAs, and contribute to better prevention and therapy of CNS infection. |
| Databáze: | OpenAIRE |
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