Effects of Dietary Korean Proso-Millet Protein on Plasma Adiponectin, HDL Cholesterol, Insulin Levels, and Gene Expression in Obese Type 2 Diabetic Mice
| Autor: | Myeong-Rak Choi, Takashi Nagasawa, Kyung-Ok Park, Naoyuki Nishizawa, Yoshiaki Ito |
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| Rok vydání: | 2008 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty medicine.medical_treatment Mice Obese Blood sugar Type 2 diabetes Biology Panicum Weight Gain Plant Proteins Dietary Applied Microbiology and Biotechnology Biochemistry Analytical Chemistry Mice chemistry.chemical_compound Diabetes mellitus Internal medicine medicine Animals Insulin Molecular Biology Glycemic Korea Adiponectin Tumor Necrosis Factor-alpha Cholesterol Cholesterol HDL Organic Chemistry General Medicine Lipid Metabolism medicine.disease Dietary Fats Obesity Endocrinology Adipose Tissue Diabetes Mellitus Type 2 Gene Expression Regulation Liver chemistry Biotechnology |
| Zdroj: | Bioscience, Biotechnology, and Biochemistry. 72:2918-2925 |
| ISSN: | 1347-6947 0916-8451 |
| DOI: | 10.1271/bbb.80395 |
| Popis: | We investigated the effect of dietary Korean proso-millet protein concentrate (PMP) on glycemic responses, plasma lipid levels, and the plasma level and gene expression of adiponectin in obese type 2 diabetic mice under normal and high-fat feeding conditions. The findings were that the feeding of PMP clearly elevated plasma high-density lipoprotein cholesterol (HDL cholesterol) and adiponectin levels and brought about effective reduction in the levels of glucose and insulin in mice under high-fat diet conditions as compared with a control diet. Gene expression study revealed that the diet up-regulated expression of adiponectin and down-regulated tumor necrosis factor-alpha (TNF-alpha). Considering the central role of adiponectin and HDL cholesterol in improving and ameliorating type 2 diabetes, obesity, and cardiovascular disease, our findings imply that PMP may have potential for therapeutic intervention in type 2 diabetes. |
| Databáze: | OpenAIRE |
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