Modeling bladder cancer in mice: opportunities and challenges
| Autor: | Cory Abate-Shen, Takashi Kobayashi, James M. McKiernan, Tomasz Owczarek |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Oncology
medicine.medical_specialty General Mathematics Mice Transgenic urologic and male genital diseases Article Mice Internal medicine Medicine Animals Humans Neoplasm Invasiveness Invasive carcinoma Bladder cancer business.industry Extramural Applied Mathematics Cancer medicine.disease female genital diseases and pregnancy complications Disease Models Animal Urinary Bladder Neoplasms Fatal disease business Neoplasm Transplantation Genes Neoplasm |
| Popis: | The prognosis and treatment of bladder cancer have improved little in the past 20 years. Bladder cancer remains a debilitating and often fatal disease, and is among the most costly cancers to treat. The generation of informative mouse models has the potential to improve our understanding of bladder cancer progression, as well as to affect its diagnosis and treatment. However, relatively few mouse models of bladder cancer have been described, and in particular, few that develop invasive cancer phenotypes. This Review focuses on opportunities for improving the landscape of mouse models of bladder cancer. |
| Databáze: | OpenAIRE |
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