Early elevation of cathepsin B1 in human muscle disease
| Autor: | Carl M. Pearson, Nirmal C. Kar |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
chemistry.chemical_classification
Cathepsin medicine.medical_specialty Pathology medicine.diagnostic_test Proteolysis Skeletal muscle Neuromuscular Diseases Disease Biology medicine.disease Cathepsins Biochemistry Polymyositis Muscular Dystrophies Cathepsin B1 Enzyme Endocrinology medicine.anatomical_structure Muscular Diseases chemistry Human muscle Internal medicine medicine Humans |
| Zdroj: | Biochemical Medicine. 18:126-129 |
| ISSN: | 0006-2944 |
| DOI: | 10.1016/0006-2944(77)90059-x |
| Popis: | Cathepsin B1 activity was determined in skeletal muscle of control subjects and of patients with major forms of muscular dystrophies, polymyositis, and certain denervating diseases. Cathepsin B1 activity was markedly increased in all diseases examined. This enzyme may thus play an important role in various muscle-wasting conditions in humans and, in fact, it may function as at least one rate-limiting enzyme of proteolysis in diseased muscle. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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